Chronic Gastritis and Acid Reflux
Answered by
Kevin Pho, MD
Boston - MA
This forum is for questions regarding Gastroenterology issues such as
Acid Reflux (GERD), Barretts Esophagus,
Colitis, Colon/Bowel Disorders,
Crohn's Disease, Diverticulitis/ Diverticulosis, Digestive Disorders,
IBS, Stomach Pain.
According to Professor Jonathan Brostoff (consultant physician, Middlesex hospital, London), there was evidence that "yeast" was involved in some cases of IBS, and some patients had reduced numbers of lactobacilli and bifidobacteria (so-called "friendly" bacteria) in their guts. Indirect evidence came from the use of tetracyclines, which, when added to a standard stool population, increased yeast production and reduced counts of lactobacilli and bifidobacteria.
Lactobacilli might induce immunological hormones, which could alter mucosal response in the gut, and there was some evidence that different grains, such as wheat, oats and rice, altered the gut flora to varying extents.
Colonic fermentation
Dr John Hunter (consultant gastroenterologist, Addenbrooke's hospital, Cambridge) said that there was evidence of abnormal colonic fermentation in IBS, which could be associated with food intolerance. A trial at Addenbrooke's had shown that colonic hydrogen production was higher in patients with IBS than controls, and the use of an exclusion diet reduced both gas production and symptoms. Future developments in the management of IBS might therefore be related to modification of gut flora and there was much interest in the potential role of prebiotics and probiotics in this area. However, a trial of oligofructose (a prebiotic) at Addenbrooke's had shown no therapeutic value in patients with IBS, he said.