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Gastroenterology  (Expert Forum)
 | 
Nail abnormalities
Answered by
Kevin Pho, MD - Internal Medicine
Kevin Pho, MD Boston - MA
This forum is for questions regarding Gastroenterology issues such as Acid Reflux (GERD), Barretts Esophagus, Colitis, Colon/Bowel Disorders, Crohn's Disease, Diverticulitis/ Diverticulosis, Digestive Disorders, IBS, Stomach Pain.

Nail abnormalities

by ALybella, Jul 13, 2006 12:00AM
I am a 27 year old healthy female.

While pregnant 2 years ago, I was not getting sufficient food intake and not taking my vitamins. At around 5 months into the pregnancy, my nails began to grow out a complete opaque white from the root, (they did not turn white, and they grew out white). I began taking my vitamins, and the nails slowly grew back normally. At the time no renal or liver abnormalities on blood work, Dr. said it was nothing to worry about. Problem resolved. About six months later after chronic severe stress, I began to have some white lines grow again, not uniformed on several nails. Some nails just had minor spots other had lines that were not even and did not follow the lunula, had renal and liver panel all normal. This happens now about twice a year, always following a traumatic experience for some reason, for example my moms near overdose. My concern is that I always read online that this could be a liver problem. My Doc just performed a physical, said no liver enlargement, he said the liver felt very good., no organ enlargement   My LFT are as follows



total protein:7.3

Albumin: 3.8

Globulin: 3.5

ALT: 15

AST: 20

Ratio: 1.3

Alk Phosp: 45

Bill total: 0.5

All CBC within normal range, Platelets 285, WBC 8.0

All within limits.

PT: normal

PTT: normal

No loss of appetite

Normal stools

Normal abdominal  CT Scan

Only slight pressure on right side of flank by belly botton, Dr. said it’s too low to be liver associates



Doctors don't seem to care about these nail changes. I do suffer from Seborrhea Dermatitis, but no other skin disease, also some diagnosed eczema on back. I'm real concerned about this being a liver problem, even though all panels for the last 2 years (almost 6) have shown up completely normal at an optimal level. Could this be caused by stress or something less serious?



Ex: The lines grow out, they are not identical, some follow the proximal fold but not all the length around, usually like a crescent shape. Not all fingers, almost always ring and pointer on left hand involvement.  I read that Terry’s nails and Muerckes lines are associated with liver disease, can these abnormalities be liver disease aswell, despite normal LFT’s, CT Scan and physical examination.





by Kevin Pho, MD, Jul 14, 2006 12:00AM
Nail changes can be indicative of liver problems.  However, with normal LFTs, this would be less likely.  Imaging the liver with an ultrasound can provide further evaluation, but I probably won't go much further than that.



If the nail changes continue, a referral to a dermatologist can be considered for further evaluation.  Sending part of the nail off for culture can be considered to evaluate for fungus.  



These options can be discussed with your personal physician.



Followup with your personal physician is essential.



This answer is not intended as and does not substitute for medical advice - the information presented is for patient education only. Please see your personal physician for further evaluation of your individual case.



Kevin, M.D.

kevinmd_
Member Comments (11)

by ALybella, Jul 13, 2006 12:00AM
By the way, I look at Mee's, Terry's nails and Muerchkes lines, my lines do not resemble any of those.  My actual nails is a pinkish color.

by ALybella, Jul 13, 2006 12:00AM
Is it true that you can have cirrhosis and perfectly normal liver enzymes??? If you had cirrhosis would your liver feel enlarged upon physical examination?  Or via abdominal CT scan

by kmz123, Jul 13, 2006 12:00AM
No your liver shrinks when you have cirrosis and that would

come up on a Ct scan.

by ALybella, Jul 14, 2006 12:00AM
Anyone, any comments on nail changes

by yoshi, Jul 14, 2006 12:00AM
Some diseases that can affect the shape, integrity and colour of the nail include:

Lung disease

Heart disease

Kidney disease

Liver disease

Thyroid disease.

by diamond79, Jul 14, 2006 12:00AM
I have the same problem with my nails. Ever since I was pregnant with my son (he is now almost 2 years old). They are in horrible shape--esp. my thumb nails. They have craters and lines going horizontal across them. Some of them curl down at the tips as well. And they are extremely brittle (peel all the time). I asked my dr. about them and he didn't have a clue. He asked if I closed them in a door or something--which I ahve not. He then figured some sort of dificiency...but didn't bother testing. I have had my liver checked just before I had my GB removed and it was fine so it can't be that. I admit, my diet isn't the greatest in the world but alot of other people are worse then me and don't have nail problems like I do. If you find the answer to your nail problem please post as I am curious to know what is the cause!