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Questions posted in the
Neurology and Neurosurgery Forum have been answered by doctors from The Cleveland Clinic Foundation.
Question Title: Could it be the baclofen?Forum: Neurology Forum
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My daughter had a baclofen pump placed at CCF in June of this year. She also has epilepsy and is currently on tegratol and just recently started the ketogenic diet. Her seizures have gotten worse since having the pump placed but we are not sure if it's the baclofen or the tegratol. The teg has never done much for seizure control and they acytually got worse with each increase. Her baclofen pump is set at 100 mcg per day, is this enough to cause seizures to worsen? I also want to say how wonderful this message board is, it helps people looking for answers and I am sure it is a great learning expercience for the residents. I have read others posts and answers and think the residents are doing a wonderful job in relating with people. Just wanted to say thanks for making this available and thank the residents for their time. Of then two drugs you mention the baclofen is most likely to be associated with this increase in seizure frequency. Intrathecal baclofen therapy has been reported as a side effect of baclofen administered by this route, biothninpeople whio have a background history of epilepsy and in people whi never had seizures before baclofen therapy. This is often an indication that the dosage it too high for that particular individual and reduction of the dosage may be sufficient to achieve seizure control. It does not sound like the tegretol is doing much good at this point, but it is a widely used anti-convulsant and I would be hesitant about discarding it without first looking at the baclofen which is the more likely culprit. I have attached a reference which discusses this topic, you may wish to draw your physician attention to it. Kofler M. Kronenberg MF. Rifici C. Saltuari L. Bauer G.
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