Questions posted in the Neurology and Neurosurgery Forum have been answered by doctors from The Cleveland Clinic Foundation.

Question Title: Anti Mag Test for Small Fiber Sensory neuropathy

Forum: Neurology Forum
Topic: Neuropathy


I was diagnosed with small fiber sensory neuropathy. I have had every conceivable test done and all have come back negative. The ony test I haven't got back yet is the Anti Mag test. My doctor said if that is positive that there is some kind of treatment. Do you have any idea what that treatment is.?
Also, I was told that B12 shots can be helpful even if your B12 is normal.
Can you let me know about these two things please! Thanks

=
A number of theraputic alternatives have been tried with success in MAG
associated neuropathy, the main lines of treatment have been aimed at removing
abnormal antibodies fron the serum by means of :
(1 )Plasmapheresis which filters antibodies from the blood.
(2 )Intravenous immunoglobulin , an intravenous preparation of pooled human
antibodies which bind to and inactivate the antibodies causing the
neuropathy.
(3) Interferon injections which modify the activity of the immune system,
thereby redcuing the intensity of the immune mediated attack on the
peripheral nerve myelin.
There are some reports that B12 injections help neuropathy in the absence of
documneted deficiency. If no other options are coming up I would suggest
you try it, since it is a supplement of a normal substance and has no side
effects and therefore you havve nothing to lose.
Reports of success are sporadic and unpredictable but it is certainly
worth trying.



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