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Questions posted in the
Neurology and Neurosurgery Forum have been answered by doctors from The Cleveland Clinic Foundation.
Question Title: dilantin, tegritol, phenobarbitol and degenerative joint/disc diseaseForum: Neurology Forum
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I have been on one or more of the above mentioned drugs for ove 25 years. I have suffered from degenerative disc disease for the past 10 years. I have seen dilantin and phenobarbitol listed as being contributory to osteoarthritis and DJD. Where can I find more information on the correlation? Thank you in advance. HW The asociation between phenytoin and phenobarbitol and osteoarthritis or DJD is a fairly weak one, I have performed a 20 year literature search in Medline which cross references 3,600 medical journals for every year, I could only find a reference to one case and I have attached the reference below, I hope you can use it to further your researches. = Stalnikowicz R. Mosseri M. Shalev O. Phenytoin-induced arthritis. Neurology. 32(11):1317-8, 1982 Nov.
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