Questions posted in the
Neurology and Neurosurgery Forum have been answered by doctors from The Cleveland Clinic Foundation.
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Subject: Neurofibromatosis and hormone replacement thearpy Topic Area:Posted by ]a href=}mailto:CLJen2@aol.com}{Christine Jenkins]/a{ on May 04, 1999 at 11:41:45]P{]br{: ]h4{Topic Area: Neurofibromatosis]/h4{]br{: : Does hormone replacement thearpy (i.e., Prempro) have any affect on tumor (neurofibroma) growth? I have noticed an incease of neurofibromas - as well as enlargement of existing neurofibromas, but am not sure whether or not to attribute it to the regular progression of the disorder or to the hrt.]p{:]p{: Dear Sheila:]p{: I am sorry to hear that your neurofibromas are increasing in size. I really do not know of any data to suggest that sex steroids would influence the size or numbers of neurofibromas. In addition, I do not know of any studies suggesting that these are in anyway influenced by sex steroids. As most replacement steroids are designed to mimic the natural states of sex steriods or somewhat reduced in levels but still retaining the effect, I would doubt that a continuing of sex steriods would influence neurofibromas. The most likely situation is that the natural progression of the neurofibroma and the disease is occuring. If I find anything I will put a posting on the site.]p{: Sincerely,]p{: CCF Neuro[P] MD]p{ ]br{Dear Sheila:]br{:My name is Christine. I have NF-2 and have posted a response prior to this one. HRT and Neurofibromatosis is still questionable. I have used HRT in the past and experienced tumor growth acceleration first-hand. If you are having the same experiences, then I suggest stopping the Prempro before things get out of control. I believe that my use of hormones in the past has led me to where I am presently, which is facing major surgery for removal of a meningioma on my temporal lobe, tumors in the orbit of my left eye and optic nerve. If you }feel} like the growth acceleration is directly related to the HRT, then it probably is true. I know that the natural progression pertaining to my case wPosted by Christine on May 25, 1999 at 23:45:39
To the dynamite doc from Cleveland, my surgery was a success. My vision is intact and I'm superbly thankful. Three arenas of medicine were involved. Neurosurgeon, Oculo-plasty Opthalmologist and a Cleft and Cranial Anamolies Reconstructive Plastic Surgeon. It all happened at Emory in Atlanta. I spent an entire year in Pain Therapy learning to deal with everything. Six days before the surgery, I participated in "Imagery" for its calming effects then took my Goldfish Pond with me into surgery. I made it. Life has changed for me. I will have to participate in Radiosurgery because of unremovable schwannoma located in my cavernous sinus. Wonderful! Let's do it! My personal Neurologist has been helping me cope with pain since 1995 and soon we will be taking me off MS-Contin in 15 mg intervals along with the stupid Ritalin I have to take for focus. Narcotics have some serious side-effects... and I cannot tolerate lack of focus. Writers on narcotics end up self-shredding, if you get my drift. My pain has regressed. Get me off so I can get on with life. You are the Dynamite Doc who commands respect. Let's keep exchanging NF research. Everything needs to be known. Knowing that I have no meningioma is in a class all by itself. I am thankful. Neurontin will always be for me. You know your stuff and I back you up. Have a good one, Doc. I have one last question. Do you know any Neurologists at Emory? Sincerely bald, Christine
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