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Questions posted in the
Neurology and Neurosurgery Forum have been answered by doctors from The Cleveland Clinic Foundation.
Question Title: isaacs syndrome - benign fasiculationsForum: Neurology Forum
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My husband was diagnosed with benign fasiculation then later Isaac's Syndrome. So far he has tried Klonopin, Quinine, Tegretol, Dilantin, etc. None seem to help except the Klonopin which takes the edge off of the nervousness and tingling he has. It does not help the muscle jerks at all. He has had this for 11 years and is in otherwise good health. These muscle jerks started in the legs and have now progressed to all parts of the body. There is no wasting of the muscles. Is there any help out there other than what we've found. We are desperate for an answer. After a while it tends to weigh on you physically and especially emotionally. Thanks for any help. The standard treatment of Isaac's syndrome is phenytoin and carbamazepine and valproate are used as a second line agents, it would appear however that your husband has tried almost the entire range of pharmacological therapies available, There have been reports of good success in some cases with the use of plasmapheresis, followed by steroids. This therapy has not been subjected to a large clinical scale trial but some anecdotsal reports have been very positive, I suggest that you mention this option to your neurologist.
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