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Questions posted in the
Neurology and Neurosurgery Forum have been answered by doctors from The Cleveland Clinic Foundation.
Question Title: Symptoms of AmyloidosisForum: Neurology Forum
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I understand that amyloidosis is a neurological condition and that an enlarged tongue can be a symptom. What are the other symptoms of this disease and is the onset of the disease slow or does it advance rapidly? Are fasciculations a common symptom? Muscle weakness? Thank you for your help. Amyloidosis is in fact a multisystem disease which sometimes may effect the nervous system. It involves the deposition of protein aggregates in various tissues and can be either a genetic condition or may occurr in response to another pathological condition,for example chronic inflammation. The age of onset and progression of amyloidosis is largely dependent on the underlying cause with more rapid evolution in the familial (inherited) types. The neurological manifestations usually declare themselves in the form of peripheral neuropathy, with numbness and weakness of the peripheries. The major problems tend to result from deposition of amyloid in opther organs including the heart, bowel and kidneys. deposition in the tongue is possible. Muscle weakness is frequent and fasiculations are possible in any condition where the peripheral nerve supplying a muscle is damaged.
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