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Questions posted in the
Neurology and Neurosurgery Forum have been answered by doctors from The Cleveland Clinic Foundation.
Question Title: Can Symptoms be severe on some days and milder on other daysForum: Neurology Forum
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I have yet to have the formal dx of CMT however my emg tests show zero conduction on some nerves and very slowing on others both arms and legs. I have noticed that on some days I have energy and other days, it is a struggle to get through the day because of fatigue, weakness. I have severe neuropathy in feet and take medication daily for pain control.. I have noticed now that repetitive motions such as holding a car wash hose and washing the car will affect me by severe weakness in that arm and an inability to hold a pen or fork for hours afterwards. My mother has been dx with CMT by blood testing.. Will I have to undergo muscle or nerve biopsy to have this testing completed or is the blood testing sufficient, and are these symptoms typical of CMT or worse??
Thanks for your question. The symptoms described in your message can be found in Charcot-Marie-Tooth Disease (CMT). Until the develop of recent DNA test, it was fairly common to obtain a biopsy of peripheral nerve (e.g. sural nerve near the ankle) for a proper classification of the subtype of CMT. For instance, CMT type I is classically associated with lesions to the myelin (fatty covering) of peripheral nerves and the so-called "onion bulb formations". On the other hand, in CMT type II nerve biopsy would reveal axonal loss (i.e. loss of the nerve conducting fibers) without significant loss of myelin. The common forms of CMT have automossal dominant inheritance, that is If you live near the Cleveland area, the Neurology Department at the I hope this information is helpful. This information is provided for general medical education purposes only.
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