Questions posted in the Neurology and Neurosurgery Forum have been answered by doctors from The Cleveland Clinic Foundation.

Question Title: What would cause elevated AChR Ab

Forum: Neurology Forum
Topic: Myasthenia Gravis

I'm aware that myasthenia gravis will cause an increase in AChR Ab,
what other conditions could cause more that a boarderline response to this test?

Are the antibodies only created in the thymus or can they also be created in the bones and would that cause a slightly elevated Alk Phos in the bone Fraction?

Dear LB Brown,
Thank you for the question,
AChR Ab is very specific for Myasthenia Gravis. The specificity is around 97-98 percent in Generalized and Ocular MG . It is only about 60 % sensitive in Ocular MG but 90% sensitive in Generalized MG.

AChR Ab has been found in experimental MG and in medication-induced
MG from D-penicillamine ( a copper chelating agent used in treatment
of Wilson's disease).

I am not sure about the bones but I doubt, and elevation in Alk Phos is
fairly non specific.

I hope this helps.
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