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Questions posted in the
Neurology and Neurosurgery Forum have been answered by doctors from The Cleveland Clinic Foundation.
Question Title: Zyprexa and decreased risk of neurological symptomsForum: Neurology Forum
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I have been taking Zyprexa for two weeks. Though it is usually indicated for people with schizophrenia, my psychiatrist informed me that it has also proven to be effective for people suffering with major depression characterized by muddled thinking and poor memory, such as myself. He was right on target! I have experienced a kind of clarity that has made me continually recall the book (and movie), "the Awakenings" My question is, what sets this medication apart from the other major psychotropic medications? I have heard that there is a decreased risk of T.D and the other unfortunate adverse reactions that often accompany usage of the other drugs in this class. Also, I have been in the "wait and see" group for M.S after an episode that suggested scattered CNS involvement (dizziness, tinnitus, parasthesias, light sensitivity) All symptoms have remitted - I have been symtom free for 4 months now. However, given my uncertain status, should there be any additional concerns taking this medication? Thank you for your valued time!
= Thanks for your question. The following is a quote from the Zyprexa's (Olanzepine) manufacturer literature: "Olanzapine is a selective monoaminergic antagonist. The mechanism of action of olanzapine, as with other antipsychotic drugs, is unknown. However, it has been proposed that this drug's antipsychotic activity is mediated through a combination of dopamine and serotonin type 2 (5HT2) antagonism. Antagonism at receptors other than dopamine and 5HT2 with similar receptor affinities may explain some of the other therapeutic and side effects of olanzapine. Olanzapine's antagonism of muscarinic M1- 5 receptors may explain its anticholinergic effects. Olanzapine's antagonism of histamine H1 receptors may explain the somnolence observed with this drug. Olanzapine's antagonism of adrenergic alpha1 receptors may explain the orthostatic hypotension observed with this drug." Amongst the possible side-effects of this medication are: orthostatic Regarding your current MS evaluation, there is some overlap between possible I hope this information is helpful. Best of luck.
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