Questions posted in the
Neurology and Neurosurgery Forum have been answered by doctors from The Cleveland Clinic Foundation.
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Subject: Re: oligodendroglioma : I have a brotherinlaw with oligodendroglioma. He has had two surgerys and is only in his early 30's. Help let me know if there is other treatment he is going through chemo . Thanks.
= Dear Laura and Ken: Oligodendrogliomas constitute about 5 to 7 percent of glial brain tumors. These tumors may be well-differentiated (relatively benign) or anaplastic (relatively malignant). Oligodendrogliomas are chemosensitive tumors. The standard treatment of anaplatic oligodendrogliomas is surgery (if feasible), radiation, and thereafter chemotherapy called PCV (procarbazine, CCNU and vincristine) given in 6 week cycles. The latter therapy was pioneered by neuro-oncologists at the University of Western Ontario, London, Canada, and is practised worldwide now. The value of radiation in the treatment of well-differentiated oligodendrogliomas is doubtful; these tumors, however, have recently also been shown to be responsive to the PCV regimen. Chemotherapy works for both newly-diagnosed and recurrent oligodendroglioma. | |
