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Neurology (Expert Forum)
Muscular problem or drug side effect
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Muscular problem or drug side effect
by MikeJ, Nov 15, 2004 12:00AM
I'm a 28 year old male, and recently took Cipro (4 weeks) and then Levaquin (4 weeks) for a prostate infection. I was fine on the Cipro, but started to experience muscle twicting a couple of days after switching to Levaquin. Since I've stopped taking the Levaquin (7 weeks ago), I've continued to have muscle twitching and burning muscle pain. The muscle twitching involves just a small part of the muscle and is sporadic. The twitching usually occurs in the calves, but I also notice it in the arms, back, butt, and feet. Sometimes it is just a single twitch, and other times it is a couple in a row. The burning/achy pain is somewhat all over (like after the flu), but usually in upper arms, shoulders and thighs. One of my calves also seems a little stiff, but I don't know if it's related. I can move my leg fine, just the upper part of the calf (below/around the knee) seems tight.
So far I've gone to my primary care physician, and he did some strength tests and tested my reflexes... he said all were perfectly normal, and there was no need for me to see a Neurologist. He seemed to think everything could be benign, and possibly caused by stress/anxiety. He didn't mention the Levaquin though.
My questions:
Do you think my symptoms could be caused by the Levaquin?
If not, what would cause them?
How does stiffness start in motor neuron disease, and would it start before weakness?
If I went to a Neuro, would they even do an EMG if strength and reflexes were fine?
Thanks for your time.
So far I've gone to my primary care physician, and he did some strength tests and tested my reflexes... he said all were perfectly normal, and there was no need for me to see a Neurologist. He seemed to think everything could be benign, and possibly caused by stress/anxiety. He didn't mention the Levaquin though.
My questions:
Do you think my symptoms could be caused by the Levaquin?
If not, what would cause them?
How does stiffness start in motor neuron disease, and would it start before weakness?
If I went to a Neuro, would they even do an EMG if strength and reflexes were fine?
Thanks for your time.
Doctor's Answer
by CCF-Neuro-M.D.-CS, Nov 18, 2004 12:00AM
I am aware of no relationship between your symptoms and Levaquin. I cannot find any references to suggest that the Levaquin caused this. It is possible that these symptoms are a reaction to a viral illness, or possible from stress (as your primary doctor suggested). If your examination is entirely normal then there may be no use for an EMG. I think it is unlikely that this represents motor neuron disease. Good luck.
The muscle problems you are refering to are identical to what i have been suffering for years and it all came from the cipro and levaquin being given to me for kidney infections. It is harder than hell to find anyone out there who will help find ways to help heal our bodies, they seem to be avoiding it at all cost. I take msm/glusamine, glutamine zinc magnesium and a multi vitamin along with Ultram for the pain and soma to relax the muscles somewhat so I can try and function. Today i am suffering from serious pain in my left elbow and I can't find anyone to take it serious, they checked for nerve damage bone damage and la la la .... they don't want to hear it's the cipro and my tendon is in danger. My body hurts everywhere, my muscles are so big you would think i work out, but i don't i can barely walk on some days and lifting something is a joke. Although the muscles are huge they are weak makes sense doesn't it. Get a lawyer, get on the quinolone page RxBoard - Levaquin (levofloxacin) - Message Index and find the petition for the congress to investigate this injustice done to so many of us who have lost everything. Good luck in your search and your recovery.
Barb
There are thousands upon thousands of people damaged by quinolones each year. Yet the medical class ignores all about this daily tragedy.
The quinolones are very neurotoxic antibiotics. It is odd that in these forum no doctor tries to discard first thing that quinolones (and other drugs) are not behind every neurological disorder of unknown origin.
Most reactions to these antibiotics become symptomatic some weeks or even months after cessation of the treatment, making it very difficult to trace back the real cause of the problems.
The reaction to quinolone antibiotics can be mild, intermediate or severe. Long treatments or high doses mean intermediate to severe reactions. Most side effects are mild.
That has nothing to do with the acuteness of the reaction. Any reaction can be very acute on its onset, to gradually turn to a mild, intermediate or severe one. The process to clear an acute reaction takes on average 4 months.
Mild reactions heal in some 6 to 12 months.
Intermediate reactions need some 12 to 24 months.
Severe reactions take from 3 to 5 years and usually end up with very extensive permanente and irreversible damage, mainly neurologic, in vision and cartilages plus connective tissues.
The neurological reactions typical of a quinolone reaction are already well known by you, that are experiencing it. They include all sorts of peripheral neuropaties (sensory, motor, autonomic, with dozens of symptoms) as well as Central Nervous System (heart, organs, brain) plus many others systemic (optical neuritis).
Recently, it has been added a warning in all the package inserts of quinolones stating that they can cause IRREVERSIBLE NEUROPATIES. This should be known by all doctors because it is not a rare adverse effect.
The main point has already been suffered by all of you: no doctor admits that quinolones do such devastating lesions, but they do, so you, like many many thousands are unreported cases.
Think for instance of the New York's postal workers that received 2 months of cipro. How many of those that completed the treatment got undamaged? Apparently, no one.
Quinolones are not recommended by manufacturers and FDA for people under 18 because of the high risk of irreversible cartilage damage.
You can consult near 4.000 medical and research documents about all the kinds of lesions that quinolones cause in some forums and organisations. For instance fqresearch.org and drugvictims.com.
The bad news is that there is no protocol or treatment. Only some recommendations to follow: do not take any NSAIDS or similar, and stay away of meat that is not certified antibiotic-free because common poultry for instance has a lot of quinolones and other antibiotics on it (do not believe that the quinolones are excreted a few days before slaughter because that is another lie that has been proved false).
You are going to need the help of a caring and informed doctor. Keep on searching for one. Not all are so arrogant as to dismiss your linking between your symptoms and levaquin. Many doctors never prescribe quinolones because of the serious adverse reactions that they cause. Some pharmacists do not sell quinolones because of the same reason.
It is a shame that young athletes, very healthy become crippled by quinolones and need on average 13 doctors before they meet one that leasen to them. The rest either dismiss them or prescribe treatments for other disorders, many of which are completely counterindicated for the quinolone-toxicity-syndrome.
Some groups of medical researchers are trying to convince the FDA that the quinolones phase II and III postsurveillance are insuficient, poorly conducted and that have intentionally failed to report the elevated and disproportionate ratio of adverse effects. But the FDA isn't prone to admit any adverse effect of already marketed drugs.
Since their invention, more of half of the quinolones have been withdrawn from the market due to their fatal or dangerous profile. The remaining ones are not much different.
What the medical class needs is to become aware of this enormous tragedy, and spare the quinolones for life or death issues, where becoming crippling for many years or for life is not the question, and never use them as a first line of treatment for upper respiratory or prostate infections.
This forum should also be aware of this. Because it is a matter of time that all will become commmon knowledge, showing clearly who cares and updates his/her education and what doctors just prescribe basing his/her decisions solely on manufacturer's advertisements or completely false rules of the thumb ("quinolones are very effective