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Neurology  (Expert Forum)
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MRI suggests ALS or MS
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MRI suggests ALS or MS

by shferolie, Jan 07, 2006 12:00AM
I am seeing a spine doctor and as of November we have scheduled a laminaplasty for the first part of February.  I have pronounced spinal stenosis with a myelomalacia at the level of C5.  I am only 29 but have skeletal dysplasia.  My doctor wanted a more recent MRI before the surgery for a better reference because my first MRI was over a year old.  However with this MRI the radiologist saw the Myelomalacia and said something about it being leisions suggesting it may be ALS or MS. The radiologist however didn't have the first MRI to compare.  Is it possible to detect such conditions with a MRI?  I have no weakness, just numbness and tingling in my arms and hands (mostly hands) with flexing my neck. My symptoms have gotten a little worse since the first MRI but not much.  He has referred me to a neurologist before we go ahead with my surgery, and I am in knots worrying about this.  Do you have any advice?  Does this sound at all like ALS?



by CCF-Neuro-M.D.-PW, Jan 13, 2006 12:00AM
There is no way of radiologically diagnosing ALS. Myelomalacia just means thinning of the spinal cord at that level, and is most commonly due to an old or chronic injury at that level (like degenerative spine disease)

ALS would be an extremely rare cuase of this finding and others would be much more common

I have not seen the scan so my advise is somewhat limited though



MS can be identified by MRI but if myelomalacia is the only finding in teh cord, it is still very non-specific and most likely due to chronic injury over time from your stenosis. If you have had discrete episodes over time of neurological symptoms like loss of vision, weakness or clumisness on one side etc, then a further evaluation for MS might be warranted due to the clinical picture (and not the MRI finding above)



Good luck
Member Comments (16)

by markbos, Jan 07, 2006 12:00AM
ALS does not show up on MRI.  It is best diagnosed with EMG testing.  Clinically, the symptoms include muscle weakness and twitching (fasciculation), but never sensory changes since ALS is a purely motor neuron disease.  You do not seem to have any of the symptoms of ALS.



MS plaques can show up on a cervical spine MRI.  MS is part of the differential diagnosis for patients with spinal cord damage, especially if caused by stenosis. It is reasonable to be worked up for MS with further MRI (brain), VEP and/or CSF testing.  However, in the absence of any motor weakness, visual problems, brainstem dysfunction, sphincter disturbances or other neurological problems, MS would seem unlikely.  The sensation changes your experiencing in your arms are called Lhermitte's sign which indicates some type of spinal cord damage, but does not specify a cause in and of itself.  I think seeing a neurologist before your surgery would be a good idea.      



by shferolie, Jan 07, 2006 12:00AM
Thanks!  I have been in knots worrying about this, and you have made me feel much more at ease.  You really seem to know a lot about this.  Are you a doctor or studying to be?  Thanks for your imput.



Are you saying that people with stenosis are more likely to get MS?

by markbos, Jan 07, 2006 12:00AM
People with stenosis are not more likely to get MS.  They are 2 entirely different problems.  Spinal stenosis can cause cord damage by direct compression, while MS can demyelinate/inflame parts of the cord.  Sorry, if my phrasing was confusing to you.  Since both spinal stenosis and MS can effect the spinal cord, there can be similar symptoms/exam findings for both problems, hence the need to consider both possibilities in a differential diagnosis.

by shferolie, Jan 07, 2006 12:00AM
To: markbos
I see.  Thanks.  I have another question for you.  Is there a difference between myelomalacia and leisions?  I'm not sure why the first MRI showed myelomalacia and the second leisions.  Also do you think the radiologist was just mistaken when he suggested the MRI showings to be ALS along with MS?

by markbos, Jan 08, 2006 12:00AM
Unfortunately, I am not a radiologist, so I am unable to comment on different lesions of the cord and their appearance on MRI.  As with all medical specialists, there is quite a bit of variation among radiologists and their skill level.  I think the best thing to do when questions such as these arise is to have another radiologist (preferably at a university hospital or large specialty medical group) look at both MRI's and comment on them. My best guess about the ALS on the report is that it may be a dictation error.  Errors on radiology reports are not that uncommon-I've seen quite a few myself.

by motheroftwo, Jan 09, 2006 12:00AM
ALS in the later stages can show up on a mri, but not in all pals.

by shferolie, Jan 10, 2006 12:00AM
To: markbos
I am going to see a neurologist tomorrow and my spine doctor has sent my my films and MRI report to take with me.  It also includes ADEM as a possibility.  Do you know much about this and whether or not it is likely?

by markbos, Jan 10, 2006 12:00AM
ADEM is an acronym for acute disseminated encephalomyelitis (ADEM).  It results in demyelination of the CNS and can look similar to MS on MRI which is probably why it was mentioned.  It seems very unlikely, based upon your symptoms, that you have ADEM.  The signs and symptoms typically include headache, fever, alterations of consciousness, paraplegia or quadriplegia if there is spinal cord involvment and multiple neurological abnormalities.  Neurological signs often involve many different areas of the nervous