I am a 47 yr old woman w/dx of fibromyalgia (12 yrs), chronic cystitis (25 yrs.from intercourse), surgery-induced menopause, MVP, and hypothyroidism (all well-managed);otherwise good health until early '04. Had rarely had a HA & no family history of HBP. Was having nights sweats & severe hot flashes for several mos & began developing pain in jaw & hands. Dx was arthritis. Several mos. later, TSH was 10. (6/04), the daily rt-sided pressure-type HAs began. OTC meds didn't help. Rheumatoligist ordered MRI (was open). Tech called it normal; went to a neuro, who pointed out lesions (didn't tell me she suspected MS). By 9/04 BP was to 170/120, constant tinnitus, nodules on hand joints, oral ulcers, & tingling in hands/feet. Blood tests showed ANA of 1:2560 w/all other tests normal. Neuro continued treating my HA, w/little results. 11/04 pain began in hips/thighs/lower back. Another head MRI (closed) was normal. BP up again;24 hr urine test & Echo were neg. 5/05 blood in urine w/no infection. Referred to Urologist-abdominal/pelvic CT normal. BP up again-referred to nephrologist. LDL up-other tests normal. Pains in hips/legs got worse. Crown of my head is tender to touch. Dr concerned about blood in urine/HBP/HAs-sent me to Mayo to rule out Lupus & ck my kidneys. Tests were normal exc ANA is 1:2560. Dx was possible Lupus. ALT, AST, ALK P, Tbili have increased (2-3x) in past 2 yrs. but at highend of nml Tingling spread to entire body;tenderness on head is spreading;legs sometimes give out. RNP,SCL70,DNA,SM,SSA,SSB,ESR,ALB,CRP,RA are nrml. What should I do next? Insist on LP? Help!