Questions posted in the The Urology Forum have been answered by urologists from Henry Ford Health System and by Dr. Kevin Pho.

Subject: Re: Interstitial Cystitis
Forum: The Urology Forum
Topic Area:
Posted by HFHS M.D.-MS on February 06, 1998 at 16:45:33:
In Reply to: Interstitial Cystitis posted by Beth Bateman on February 05, 1998 at 15:11:27:



After a bout of heavy bleeding I was sent to a specialist who suggested that I have a hysterectomy. A month later the surgery was done but not without complications. The problem consisted of two extra surgeries to correct an uterine pedicle which could not stop bleeding. After this I had an infection in the bladder. After several medictions I still was showing signs of infection. It took several months to be diagnosed with IC. Since then I have read several articles stating that a high percentage of women who had a hysterectomy ended up with IC. My question to you is there any connection between the two. I did not have IC before my hysterectomy.
I would appreciate your answer to this question. Also I am interested in any information regarding IC and articles suggesting that pelvic surgery is associated with IC.

+++++++++++++++++++++++++++++++++++++++++++++++++++++++++
Dear Beth;
Thank you for your question.
Your theory is intriguing.
I was not aware of an association until I did a medline literature search over the last 4 years and found this very pertinent article. This does not mean there is a causal relation.
The abstract states that the mean age for the onset of IC, interstitial cystitis was 42.5 years and 44% of patients related the beginning of symptoms to a hysterectomy.
Here is the abstract and the info. You can get a copy at just about any medical library. Remember to bring some change for the copier. This article may reference other articles which have or have not found similar associations.

Koziol JA. Clark DC. Gittes RF. Tan EM .
Department of Molecular and Experimental Medicine, Scripps Research
Institute, La Jolla, California.
The natural history of interstitial cystitis: a survey of 374 patients.
Journal of Urology. 149(3):465-9, 1993 Mar.

A survey directed at determining the natural history of interstitial
cystitis was conducted at our clinic. Information on demographics, risk
factors, symptoms, pain and psychosocial factors was elicited from 374
patients who satisfied the National Institute of Arthritis, Diabetes,
Digestive and Kidney Diseases criteria for interstitial cystitis and had
all been diagnosed as having interstitial cystitis by a urologist. With
regard to demographics, patients were predominantly female (89.8%) and
white (94.1%), with a mean age of 53.8 +/- 0.7 years (standard error)
and age at the first symptoms of 42.5 +/- 0.8 years. Information on 25
potential risk factors included 44.4% of the women reporting
hysterectomy, 38.2% of the patients having strong sensitivities or
allergic reactions to medication and only 2.7% being diabetic. With
regard to interstitial cystitis symptoms, frequency and urgency were
reported by 91.7% and 89.3% of the patients, respectively, while pelvic
pain, pelvic pressure and bladder spasms were reported by more than 60%
of respondents and burning by 56%. Location and degree of pain were also
reported. Urination relieved or lessened interstitial cystitis pain for
73.6% of the patients and medication was effective for 46.8%. Other
behaviors (for example hot baths, heating pads, lying down or sitting)
were less effective. Conversely, stress, constrictive clothing and
intercourse increased interstitial cystitis pain in more than 50% of the
patients. In addition, acidic, alcoholic or carbonated beverages, and
coffee or tea increased interstitial cystitis pain in more than 50% of
the patients. More than 60% of the patients were unable to enjoy usual
activities or were excessively fatigued and 53.7% reported depression.
Travel, employment, leisure activities and sleeping were adversely
affected in more than 80% of the patients. Pain location and degree
differed significantly between patients with and without ulcers in the
bladder. In addition, there was an apparent plateau in the frequency and
urgency among patients after approximately 5 years with symptoms.

We at HFH have a NIH (National Institute of Health ) funded grant to help understand IC better. Drs. Kirkemo and Burks are the IC specialist in our Urology department and would be happy to see and treat you. If interested please call 1800 653-6568 for an appointment.
Now; our disclaimer.
This information is provided for general medical education purposes only. Please consult your physician for diagnostic and treatment options pertaining to your specific medical condition.
Good luck and thanks for teaching me something!

Sincerely;

HFHS M.D.-MS
*Keyword: Interstitial Cystitis


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