This pamphlet was written and published by the National Institute of Neurological Disorders and Stroke (NINDS), the United States' leading supporter of research on disorders of the brain and nerves, including brain and spinal cord tumors. NINDS, one of the U.S. Government's 16 National Institutes of Health in Bethesda, Maryland, is part of the Public Health Service within the U.S. Department of Health and Human Services.
The diagnosis of a brain or spinal cord tumor often comes as a shock, leaving confusion, uncertainty, fear, or even anger in its wake. After the diagnosis, a physician's explanation can fall on ears deafened by this blow. Although it cannot substitute for the advice and expertise of a physician, this brochure is designed to convey the latest research information on the diagnosis, course, and possible treatment of various brain and spinal cord tumors, so that patients and their families have the information they need to become active participants in their treatment.
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Brain and spinal cord tumors are abnormal growths of tissue found inside the skull or the bony spinal column. The word tumor is used to describe both abnormal growths that are new (neoplasms) and those present at birth (congenital tumors). This brochure will focus primarily on neoplasms.
No matter where they are located in the body, tumors are usually classed as benign (or non-cancerous) if the cells that make up the growth are similar to other normal cells, grow relatively slowly, and are confined to one location. Tumors are called malignant (or cancerous) when the cells are very different from normal cells, grow relatively quickly, and can spread easily to other locations.
In most parts of the body, benign tumors are not particularly harmful. This is not necessarily true in the brain and spinal cord, which are the primary components of the central nervous system (CNS). Because the CNS is housed within rigid, bony quarters (that is, the skull and spinal column), any abnormal growth can place pressure on sensitive tissues and impair function. Also, any tumor located near vital brain structures or sensitive spinal cord nerves can seriously threaten health. A benign tumor growing next to an important blood vessel in the brain does not have to grow very large before it can block blood flow. Or, if a benign tumor is found deep inside the brain, surgery to remove it may be very risky because of the chances of damaging vital brain centers. On the other hand, a tumor located near the brain's surface can often be removed surgically.
An important difference between malignant tumors in the CNS and those elsewhere in the body lies with their potential to spread. While malignant cells elsewhere in the body can easily seed tumors inside the brain and spinal cord, malignant CNS tumors rarely spread out to other body parts. Laboratory and clinical investigators are exploring such unusual characteristics of CNS tumors, because these unique properties may suggest new strategies to prevent or treat them.
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When newly formed tumors begin within the brain or spinal cord, they are called primary tumors. Primary CNS tumors rarely grow from neurons -- nerve cells that perform the nervous system's important functions -- because once neurons are mature they no longer divide and multiply. Instead, most tumors are caused by out-of-control growth among cells that surround and support neurons. Primary CNS tumors -- such as gliomas and meningiomas -- are named by the types of cells they contain, their location, or both. The appendix at the end of this brochure describes many types of primary CNS tumors, as well as other tumor-related conditions.
In a small number of individuals, primary tumors may result from specific genetic diseases -- such as neurofibromatosis and tuberous sclerosis -- or exposure to radiation or cancer-causing chemicals. Although smoking, alcohol consumption, and certain dietary habits are associated with some types of cancers, they have not been linked to primary brain and spinal cord tumors.
In fact, the cause of most primary brain and spinal cord tumors -- and most cancers -- remains a mystery. Scientists do not know exactly why and how cells in the nervous system or elsewhere in the body lose their normal identity as nerve, blood, skin, or other cell types and grow uncontrollably. Research scientists are looking for clues to this process with the goals of learning why and how cancer begins and developing new tools to stop it. Some of the possible causes under investigation include viruses, defective genes, and chemicals.
Metastatic tumors are caused by cancerous cells that shed from tumors in other parts of the body, travel through the bloodstream, burrow through the blood vessel walls, latch onto tissue, and spawn new tumors inside the brain or spinal cord.
For every four people who have cancer that has spread within the body, one develops metastasis within the CNS. The top two culprits that lead to these secondary CNS tumors are lung and breast cancer. Other, less frequent causes of CNS metastases include kidney (renal) cancer, lymphoma (a cancer affecting immune cells), prostate cancer, and melanoma, a form of skin cancer.
Brain and spinal cord tumors are not contagious or, at this time, preventable.
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Research studies suggest that new brain tumors arise in more than 40,000 Americans each year. About half of these tumors are primary, and the remainder are metastatic.
Individuals of any age can develop a brain tumor. In fact, they are the second most common cause of cancer-related death in people up to the age of 35, with a slight peak in occurrence among children between the ages of 6 and 9. However, brain tumors are most common among middle-aged and older adults. People in their 60s face the highest risk -- each year 1 of every 5,000 people in this age group develops a brain tumor.
Spinal cord tumors are less common than brain tumors. About 10,000 Americans develop primary or metastatic spinal cord tumors each year. Although spinal cord tumors affect people of all ages, they are most common in young and middle-aged adults.
By studying the epidemiology of CNS tumors, scientists can learn if different tumors are more common at certain ages or in certain people. This information, in turn, may reveal environmental factors that are linked to tumors, connections between tumors and other disorders, or patterns of tumor occurence, all of which offer clues about why tumors develop.
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Brain and spinal cord tumors cause many diverse symptoms, which can make detection tricky. Whatever specific symptoms a patient has, the symptoms generally develop slowly and worsen over time.
A 3.5-pound wrinkled mass of tissue, the brain orchestrates behavior, movement, feeling, and sensation. It controls automatic functions like breathing and heartbeat. Many of these important functions are controlled by specialized brain areas. For example, the brain's left and right hemispheres jointly control hearing and vision; the front part of each hemisphere controls voluntary movements, like writing, for the opposite side of the body; and the brain stem is responsible for basic life-sustaining functions, including blood pressure, heartbeat, and breathing.
As a result, brain tumors can cause a bewildering array of symptoms depending on their size, type, and location. Certain symptoms are quite specific because they result from damage to particular brain areas. Other, more general symptoms are triggered by increased pressure within the skull as the growing tumor encroaches on the brain's limited space or blocks the flow of cerebrospinal fluid (fluid that bathes the brain and spinal cord). Some of the more common symptoms of a brain tumor include:
The spinal cord is, in part, like a living telephone cable. Lying protected inside the bony spine, it contains bundles of nerves that carry messages between the brain and the body's nerves, such as instructions from the brain to move an arm or information from the skin that signals pain.
A tumor that forms on or near the spinal cord can disrupt this communication. Often, these tumors exert pressure on the spinal cord or the nerves that exit from it; sometimes, they restrict the cord's supply of blood. Common symptoms that result from this include:
The parts of the body affected by these symptoms vary with tumor location along the spinal cord. In general, symptoms strike body areas at the same level or at a level below that of the tumor. For example, a tumor midway along the spinal cord (in the thoracic spine) can cause pain that spreads over the chest in a girdle-shaped pattern and gets worse when the individual coughs, sneezes, or lies down. A tumor that grows in the top fourth of the spinal column (or cervical spine) can cause pain that seems to come from the neck or arms. And a tumor that grows in the lower spine (or lumbar spine) can trigger back or leg pain.
In some cases, one or more tumors extend over several sections of the spinal cord. This results in symptoms that are spread over various parts of the body. Sometimes sensory symptoms occur in a patchy, confusing pattern in which some parts of the body are unaffected even though they lie between affected areas.
Doctors divide spinal cord tumors into three major groups based on where they are found. Extradural tumors grow between the bony spinal canal and the tough membrane called dura mater that protects the spinal cord. Tumors inside the dura (intradural tumors) are further divided into those outside the spinal cord (extramedullary tumors) and those inside the spinal cord (intramedullary tumors).
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Research has made major strides in the ability to detect and diagnose CNS tumors. When a doctor suspects a brain or spinal cord tumor because of a patient's medical history and symptoms, he or she can turn to a number of specialized tests and techniques to confirm the diagnosis. However, the first test is often a traditional neurological exam. A neurological exam checks:
Eye movement, eye reflexes, and pupil reaction. For example, the doctor can shine a pen light into the eye to see if the pupil contracts normally or ask the patient to follow a moving object, such as a finger.
The next step in diagnosing brain tumors often involves X-rays or special imaging techniques and laboratory tests that can detect the presence of a tumor and provide clues about its location and type.
Imaging and X-rays
Special imaging techniques developed through recent research, especially computed tomography (CT) and magnetic resonance imaging (MRI), have dramatically improved the diagnosis of CNS tumors in recent years. In many cases, these scans can detect the presence of a tumor even if it is less than half-an-inch across.
CT uses a sophisticated X-ray machine and a computer to create a detailed picture of the body's tissues and structures. Often, doctors will inject a special dye into the patient before performing a CT scan. The dye, also called contrast material, makes it easier to see abnormal tissue. A CT scan often gives doctors a good idea of where the tumor is located in the brain or spinal cord and can sometimes help them determine the tumor's type. It can also help doctors detect swelling, bleeding, and other associated conditions. In addition, CT scans can help doctors check the results of treatment and watch for tumor recurrence.
MRI is a relatively new imaging technique that is rapidly gaining widespread use in diagnosing CNS tumors. This technique uses a magnetic field and radio waves, rather than X-rays, and can often distinguish more accurately between healthy and diseased tissue. MRI gives better pictures of tumors located near bone than CT, does not use radiation as CT does, and provides pictures from various angles that can enable doctors to construct a three-dimensional image of the tumor.
A third imaging technique called positron emission tomography (PET) provides a picture of brain activity rather than structure by measuring levels of injected glucose (sugar) that has been labelled with a radioactive tracer. Glucose is used by the brain for energy. Detectors placed around the head can spot the labelled glucose, and a computer uses the pattern of glucose distribution to form an image of the brain. Since malignant tissue uses more glucose than normal, it shows up on the scan as brighter or lighter than surrounding tissue. Currently, PET is not widely used in tumor diagnosis, in part because the technique requires very elaborate, expensive equipment, including a cyclotron to create the radioactive glucose.
Although it is not widely used for diagnosis now that CT and MRI scans are possible, angiography continues to help doctors distinguish certain types of brain tumors and make decisions about surgery. In angiography, doctors inject dye into a major blood vessel, usually one of the large arteries in the neck. This dye deflects X-rays and makes it possible for doctors to see the network of blood vessels by taking a series of X-ray pictures as the dye flows through the brain. Since some tumors have a characteristic pattern of blood vessels and blood flow, the pictures can provide clues about the tumor's type. Information from angiography can also tell physicians if a tumor is located close to important, normal blood vessels that must be avoided during surgery.
Widespread use of CT and MRI has also largely displaced use of traditional X-rays for diagnosis of brain and spinal cord tumors, since X-rays do not provide very useful images of brain tissue. They are occasionally helpful when tumors cause changes in the skull or spinal cord or when they contain tiny deposits of bone-like material made of calcium.
Physicians may also use a specialized X-ray technique, called a myelogram, when diagnosing spinal cord tumors. In myelography, a special dye that absorbs X-rays is injected into the spinal cord. This dye outlines the spinal cord but will not pass through a tumor. The resulting X-ray picture shows a dark area or narrowing that reveals the tumor's location.
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Laboratory Tests
Laboratory tests commonly used include the electroencephalogram (or EEG) and lumbar puncture, also known as the spinal tap. The EEG uses special patches placed on the scalp or fine needles placed in the brain to record electrical currents inside the brain. This recording can help the doctor see telltale patterns in the brain's electrical activity that suggest a brain tumor. Repeated EEG recordings can be particularly helpful in deciding if an abnormality in brain activity is getting worse.
In lumbar puncture, doctors obtain a small sample of cerebrospinal fluid. This fluid can be examined for abnormal cells or unusual levels of various compounds that suggest a brain or spinal cord tumor.
In the future, diagnosis of brain tumors should grow more accurate as additional techniques -- including new ways to image the CNS and advanced laboratory tests -- are developed through basic laboratory studies and clinical research.
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A biopsy is a surgical procedure in which a small sample of tissue is taken from the suspected tumor, often during surgery aimed at removing as much tumor as possible.
A biopsy gives doctors the clues they need to specifically diagnose the type of tumor. By examining the sample under a microscope, the pathologist -- a physician who specializes in understanding how disease affects the body's tissues -- can tell what kinds of cells are in a tumor. Pathologists also look carefully for certain changes that signal cancer. These signs include abnormal growths or changes in the cell membranes and telltale problems in the cell nuclei, which normally control cell characteristics and growth. For example, cancerous cells may grow small finger-like projections on their normally smooth surface or have extra nuclei.
Using this information, the pathologist provides a diagnosis of the tumor type. The tumor may also be classified as benign or malignant and given a numbered score that reflects how malignant it is. This score can help doctors determine how to treat a tumor and predict the likely outcome, or prognosis, for the patient.
Although biopsy has long been a mainstay of brain tumor diagnosis, it is still an important research area. Scientists continue to look for better ways to identify and classify types of abnormal cells in order to improve the accuracy of prognosis and provide the best possible information for treatment decisions.
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The three most commonly used treatments -- surgery, radiation, and chemotherapy -- are largely the result of recent research. For some patients, doctors may suggest a new treatment still being tested (see page XX). In any case, the doctor will recommend a treatment or a combination of treatments based on the tumor's location and type, any previous treatment the patient may have received, and the patient's medical history and general health.
Surgery to remove as much tumor as possible is usually the first step in treating an accessible tumor -- that is, a tumor that can be removed without unacceptable risk of neurological damage. Fortunately, research has led to advances in neurosurgery that make it possible for doctors to reach many tumors that were previously considered inaccessible. These new techniques and tools equip neurosurgeons to operate in the tight, vulnerable confines of the CNS. Some recently developed approaches in use in the operating room include:
Surgery may be the beginning and end of treatment if the biopsy shows a benign tumor. If the tumor is malignant, however, doctors often recommend additional treatment following surgery, including radiation, chemotherapy, or experimental treatments. Sometimes, if a tumor is very large, radiation is used before surgery to reduce the tumor's size.
An inaccessible or inoperable tumor is one that cannot be removed surgically because of the risk of severe nervous system damage. These tumors are frequently located deep within the brain or near vital structures such as the brain stem -- the part of the brain that controls many crucial functions including breathing and heart rate. Malignant, multiple tumors may also be inoperable. Doctors treat most malignant, inaccessible, or inoperable CNS tumors with radiation and/or chemotherapy.
Among patients who have metastatic CNS tumors, doctors usually focus on treating the original cancer first. However, when a metastatic tumor causes serious disability or pain, doctors may recommend surgery or other treatments to reduce symptoms even if the original cancer has not been controlled.
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In radiation therapy, the tumor is bombarded with beams of energy that kill tumor cells. Traditional radiation therapy delivers radiation from outside the patient's body, usually begins a week or two after surgery, and continues for about 6 weeks. The dosage is fairly uniform throughout the treated areas, making it especially useful for tumors that are large or have infiltrated into surrounding tissue.
However, when traditional radiation therapy is given to the brain, it may also cause damage to healthy tissue. Depending on the type of tumor, doctors may be able to choose a modified form of radiation therapy to help prevent this and to improve the effectiveness of treatment. Modifying therapy can be as simple as changing the dosage schedule and amount of radiation that a patient receives. For example, an approach called hyperfractionation uses smaller, more frequent doses. Neurological investigators are also testing several other, more complex techniques to improve radiation therapy.
Chemotherapy uses tumor-killing drugs that are given orally or injected into the bloodstream. Because not all tumors are vulnerable to the same anticancer drugs, doctors often use a combination of drugs for chemotherapy.
Chemotherapeutic drugs generally kill cells that are growing or dividing. This property makes them more deadly to malignant tissue, which contains a high proportion of growing and dividing cells, than to most normal cells. It also causes some of the side effects that can accompany chemotherapy -- such as skin reactions, hair loss, or digestive problems -- because a high proportion of these normal cell types are also growing and dividing at any given time. The drugs most commonly used for CNS tumors are known by the initials BCNU (sometimes called carmustine) and CCNU (or lomustine). Research scientists are also testing many promising drugs to learn if they can improve treatment for brain and spinal cord tumors and reduce side effects.
Tumors, surgery, and radiation therapy can all result in swelling inside the CNS. Doctors may prescribe steroids for short or long periods to reduce this swelling. Examples of such drugs include dexamethasone, methylprednisolone, and prednisone.
Whether new treatment approaches involve surgery, radiation therapy, chemotherapy, or completely new avenues to treating CNS tumors, carefully planned clinical trials of new and experimental therapies are vital for identifying promising treatments and learning the best applications of current therapies. Experimental treatments, in turn, would not be possible without research by basic and clinical scientists who identify new approaches.
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Brain and spinal cord tumors are often difficult to diagnose, and surgery to remove them demands great skill. Experience, therefore, is probably the most important factor in choosing among physicians. Brain and spinal cord tumors are also relatively rare. Many physicians see only a few patients with CNS tumors each year. Others, however, have made treating brain and spinal cord tumors their specialty. Patients should consider how many patients a physician treats each year. Because many patients are understandably perplexed or frightened by a CNS tumor diagnosis, it is also important that they choose a physician who will answer questions and describe treatment options clearly and fully.
Patients should also learn what techniques and tools are available at the physician's hospital. Teaching hospitals affiliated with a medical college or university are more likely to be involved in research and, thus, have the equipment and specialists necessary to offer experimental treatments. Finally, if a patient is dissatisfied with a physician or a physician's recommendations, he or she may wish to seek another opinion.
The voluntary organizations listed on the pocket card at the back of this publication may be able to help in locating physicians who specialize in treating brain tumors, as well as provide information about CNS tumors.
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Scientists are attacking CNS tumors through biomedical research to improve medical understanding and treatment. CNS tumor research ranges from bench-side studies on the origins and characteristics of tumors to bed-side studies that test new tumor-killing drugs and other innovative treatments. Much of this work is supported by the National Institute of Neurological Disorders and Stroke (NINDS) and by the National Cancer Institute (NCI), as well as other agencies within the Federal Government, non-profit groups, and private institutions.
Some key areas of brain tumor research include:
Scientists are also working to overcome an obstacle to effective chemotherapy for brain and spinal cord tumors -- the blood-brain barrier. The blood-brain barrier -- an elaborate meshwork of fine blood vessels and cells that filters blood reaching the CNS -- normally helps protect the sensitive tissues of the CNS from potentially dangerous compounds in the bloodstream and changes in its environment. But the blood-brain barrier also stymies many efforts to deliver anticancer drugs that may help patients with CNS tumors. Investigators are testing drugs, such as the chemical leukotriene, that may help open the barrier. If these drugs prove useful and safe in animal models and humans, then physicians would be equipped to test promising anticancer drugs that normally cannot cross the blood-brain barrier.
Another experimental path aimed at improving drug delivery into the CNS is called interstitial chemotherapy. In this technique, doctors place disc-shaped wafers soaked with chemotherapeutic drugs directly into tumor tissue. This technique may help physicians increase the dose of life-prolonging drugs while limiting side effects -- since less of the drug spreads elsewhere in the body. Most trials of this technique currently involve patients with recurrent gliomas.
Some scientists are testing the effectiveness of giving the body's immune system a general boost. Much like the way coffee can stimulate the nervous system, certain naturally occurring body chemicals trigger immune cells to grow and divide. In numerous studies, researchers have supplied patients with extra amounts of immune stimulants, such as interleukin-2, in the hope that they will improve the body's ability to fight CNS cancer. However, this technique has produced mixed results. A second type of general immunotherapy involves removing immune cells from a patient, growing and activating these cells and then returning them to the patient where they can work against the cancer. This approach has also yielded mixed results.
Another, still more recent approach in immunotherapy research specifically targets tumor cells using monoclonal antibodies. Like duplicate keys for the same lock, monoclonal antibodies are multiple copies of a single antibody; they fit one -- and only one -- antigen. Scientists are now producing monoclonal antibodies against tumor cell antigens and testing their usefulness. For example, scientists at the NINDS and elsewhere are linking these antibodies to toxins that can kill tumor cells. The armed monoclonal antibodies then function like guided missiles; they seek out the tumor cells with a matching antigen, bind to these tumor cells, and deliver their toxin. Early experiments with this therapy suggest it has more promise for treating widespread cancer cells than solid tumors. Studies are underway to corroborate these early results and to learn if this therapy has promise for other types of CNS tumors. Monoclonal antibodies may also prove helpful in improving brain tumor diagnosis, because they can be attached to special tracers to make tumor cells more visible.
Intraoperative ultrasound. This technique, which uses sound waves, provides the surgeon with an image of brain tissues during the operation. Ultrasound is less expensive and complex than other imaging techniques. Some scientists conducting research on intraoperative ultrasound have found the technique makes it easier for the surgeon to locate the outer edges of tumor tissue, which can be hard to find. Thus, this technique may help improve tumor surgery by increasing the amount of tumor that can be safely removed. Table of Contents
Although many new approaches to treatment thus appear promising, it is important to remember that all potential therapies must stand the tests of well-designed, carefully controlled clinical trials and long-term follow-up of treated patients before any conclusions can be drawn about their safety or effectiveness.
Past research has led to improved tumor treatments and techniques, providing longer survival and richer lives for many CNS tumor patients. Current research promises to generate further improvements. In the years ahead, physicians and patients can look forward to new forms of therapy developed through an understanding of the unique traits of CNS tumors.
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The NINDS and the National Institute of Mental Health jointly support two national brain specimen banks. These banks supply research scientists around the world with nervous system tissue from patients with neurological and psychiatric disorders. They need tissue from patients with CNS tumors so that scientists can study and understand these tumors. Those who may be interested in donating should write to:
Dr. Wallace W. Tourtellotte, Director
Human Neurospecimen Bank
VA Wadsworth Medical Center
Wilshire and Sawtelle Blvds.
Los Angeles, CA 90073
(310) 824-4307
Dr. Edward D. Bird, Director
Brain Tissue Bank, Mailman Research Center
McLean Hospital
115 Mill Street
Belmont, MA 02178
1-800-BRAIN-BANK (1-800-272-4622)
(617) 855-2400
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The NINDS is the Federal Government's leading supporter of biomedical research on nervous system disorders, including brain and spinal cord tumors. The NINDS conducts research on brain tumors in its own laboratories at the National Institutes of Health (NIH) in Bethesda, MD, and supports research at institutions worldwide. The Institute also sponsors an active public information program. Other NINDS publications that may be of interest to those concerned about brain and spinal cord tumors include "Epilepsy: Hope Through Research," and the fact sheets, "Neurofibromatosis" and "Tuberous Sclerosis." For more information, write or call:
Neurological Institute
P.O. Box 5801
Bethesda, MD 20824
(301) 496-5751
1-800-352-9424
The National Cancer Institute (NCI), also within the NIH, is the Federal Government's leading supporter of cancer-related biomedical research. NCI offers a variety of publications and a toll-free cancer information service. For more information, write or call:
Office of Cancer Communications
NCI
Building 31, Room 10A-24
Bethesda, MD 20892
1-800-4-CANCER (1-800-422-6237)
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Appendix
Chordomas
Chordomas, which are more common in people in their 20s and 30s, develop from remnants of the flexible spine-like structure that forms and dissolves early in fetal development and is later replaced by the spinal cord. Although these tumors are often slow-growing, they can metastasize or recur after treatment. They are usually treated with a combination of surgery and radiation.
Craniopharyngiomas
Craniopharyngiomas are brain tumors that usually affect infants and children. Like chordomas, they develop from cells left over from early fetal development. Craniopharyngiomas are often located near the brain's pituitary gland, a gland that releases chemicals important for the body's growth and metabolism. Treatment for these tumors usually include surgery and, in some patients, radiation therapy.
Gliomas
About half of all primary brain tumors and about one-fifth of all primary spinal cord tumors are gliomas, meaning that they grow from glial cells. Within the brain, gliomas usually occur in the cerebral hemispheres but may also strike other areas, especially the optic nerve, the brain stem and, particularly among children, the cerebellum. Gliomas are classified into several groups because there are different kinds of glial cells.
astrocytomas
These are the most common type of glioma. They develop from star-shaped glial cells called astrocytes. Doctors will often assign one of three grades to an astrocytoma following biopsy. The types of graded astrocytomas include:
well-differentiated: Also known as low-grade astrocytomas or grade I astrocytomas astrocytomas, these tumors contain cells that are relatively normal and are less malignant than the other two grades. They grow relatively slowly and may sometimes be completely removed through surgery. However, even well-differentiated astrocytomas are life-threatening if they are inaccessible.
anaplastic: Anaplastic astrocytomas, also called mid-grade astrocytomas or grade II astrocytomas, grow more rapidly than well-differentiated astrocytomas and contain cells with some malignant traits. Surgery followed by radiation and, sometimes, chemotherapy, is used to treat anaplastic astrocytomas.
glioblastoma multiforme: These tumors, sometimes called high-grade or multiforme grade III astrocytomas, grow rapidly, invade nearby tissue, and contain cells that are very malignant. Glioblastoma multiforme are among the most common and devastating primary brain tumors that strike adults. Doctors usually treat glioblastomas with surgery followed by radiation therapy and, sometimes, chemotherapy.
ependymomas
Ependymomas usually affect children and develop from cells that line both the hollow cavities of the brain and the canal containing the spinal cord. About 85 percent of ependymomas are benign. Treatment usually includes surgery followed by radiation therapy. Chemotherapy is sometimes used, especially for recurrent tumors.
oligodendrogliomas
These tumors, which develop from glial cells called oligodendroglia, represent about 5 percent of all gliomas. They occur most often in young adults, within the brain's cerebral hemispheres. Doctors often treat these tumors with surgery followed by radiation therapy.
ganglioneuromas
The rarest form of glioma, these tumors contain both glial cells and mature neurons. They grow relatively slowly and may occur in the brain or spinal cord. These tumors are usually treated with surgery.
mixed gliomas
Mixed gliomas contain more than one type of glial cell, usually astrocytes and other glial cell types. Treatment focuses on the most malignant cell type found within the tumor.
brain stem gliomas
Named by their location at the base of the brain rather than the cells they contain, brain stem gliomas are most common in children and young adults. Surgery is not usually used to treat brain stem gliomas because of their vulnerable location. Radiation therapy sometimes helps to reduce symptoms and improve survival by slowing tumor growth.
optic nerve gliomas
These tumors are found on or near the nerves that travel between the eye and brain vision centers and are particularly common in individuals who have neurofibromatosis. Treatment usually includes surgery or radiation.
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Meningiomas
Meningiomas are tumors that develop from the thin membranes, or meninges, that cover the brain and spinal cord. Meningiomas account for about 15 percent of all brain tumors and about 25 percent of all primary spinal cord tumors. They affect people of all ages, but are most common among those in their 40s. Meningiomas usually grow slowly, generally do not invade surrounding normal tissue, and rarely spread to other parts of the CNS or body. Surgery is the preferred treatment for accessible meningiomas and is more successful for these tumors than for most tumor types.
Pineal Tumors
Tumors in the pineal gland, a small structure deep within the brain, account for about 1 percent of brain tumors. When possible, physicians will begin treatment with surgery or perform a biopsy to confirm the tumor type. They may also recommend radiation or chemotherapy, or both, for malignant pineal tumors. The three most common types of pineal region tumors are gliomas, germ cell tumors, and pineal cell tumors.
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