Nervous System

Abnormalities of the nervous system can include seizures, paralysis, developmental and mental retardation, and small head size. Careful studies of the frequencies of these symptoms in individuals with confirmed IP are underway. Currently, it is unknown how common neurological problems are in IP. The discovery of NEMO mutations in IP has allowed more patients to be identified, leading to the appreciation that IP is more common than previously recognized.

While this is not enough information upon which to base strong conclusions, it does suggest that the vast majority of individuals with IP will be neurologically normal. There is increasing evidence that, if problems are going to arise, they will within the first year of life. Seizures or other complications should be treated as in any other infant, but these problems do not need special or unusual managements.