CSF-VDRL test
Information, Symptoms, Treatments and Resources
The CSF-VDRL test is used to diagnose neurosyphilis. This test looks for antibodies called reagins, which are sometimes produced by the body in reaction to the syphilis-causing bacteria.
See also: VDRL
The test is performed on a CSF sample obtained by lumbar puncture (spinal tap).
Before the procedure, you will be asked to review the risks and sign a consent form.
Usually, discomfort associated with the lumbar puncture is mild to moderate. The entire procedure usually takes about 30 minutes but may take longer. The actual fluid collection only takes a few minutes.
The CSF-VDRL test is used to diagnose syphilis in the brain or spinal cord. Brain and spine cord involvement usually indicates late stage (tertiary) syphilis.
Blood screening tests, such as VDRL and RPR, are more effective during middle stage (secondary) syphilis.
A negative result is normal.
However, false-negatives can occur. This means you can have syphilis and have a normal CSF-VDRL test result. Therefore, a negative test does not always rule out the disease. Other markers of inflammation, such as elevated protein levels or excess white blood cells, may be used to diagnose neurosyphilis.
- Risks of lumbar puncture include:
- Hypersensitivity (allergic) reaction to the anesthetic
- Discomfort during the test
- Headache after the test
- Bleeding into the spinal canal
- Brain herniation (if performed on a person with increased intracranial pressure) which may result in brain damage or death
- Damage to the spinal cord or nerve roots
U.S. Preventive Services Task Force. Screening for Syphilis Infection: Recommendation Statement. Ann Fam Med 2004; 2: 362-365.
A.D.A.M., Inc. is accredited by URAC, also known as the American Accreditation HealthCare Commission (www.urac.org). URAC's accreditation program is an independent audit to verify that A.D.A.M. follows rigorous standards of quality and accountability. A.D.A.M. is among the first to achieve this important distinction for online health information and services. Learn more about A.D.A.M.'s editorial policy, editorial process and privacy policy. A.D.A.M. is also a founding member of Hi-Ethics and subscribes to the principles of the Health on the Net Foundation (www.hon.ch).
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. � 1997- 2008 A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
