I have to take this also (only once or twice a day). I've gotten use to drinking it in water but before that I mixed it with ice tea (like Lipton Ice Tea or Arizona Ice Tea - the kind that's already mixed) and I couldn't taste the Cholestyramine. Try getting a small bottle of ice tea and give it a try. It dissolves and mixes better when the liquid isn't cold. Good luck with it.
It might taste nasty from time to time but it's been a god send to me for my IBS!
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