Reading these comments have really put my mind at ease. I have been on Paxil CR for about six months and have had significant weight gain. I started a new form of birth control at the same time and thought that was the culprit originally. Since I had been on Paxil years before and had had no problems I never thought it was the Paxil. I switched birth control three times to no avail. Finally went to a new doc and explained the weight gain and how I'd always maintained within five pounds. His immediate reaction was the Paxil. I have put on about 15lbs. in six months. I feel aweful. Fortunately my doc has started to wean me off the meds. So, we'll see if this helps with the weight gain. I hope so. Good luck.