Hello Melissa - I just saw your post and was wondering how you made out? I've had an abdominal seroma since 1997 when I had major reconstructive surgery. My plastic surgeon refuses to aspirate the seroma for the same reason - infection. But seroma has never resolved and just keeps getting larger - it's now the size of a small melon and causes me pain when eating. I've been told that if it get's infected, they'd have to reopen me and they say that would be a death sentence so they leave me no options.