I'm off from the Cyclosporene now and am on another run of Prednesone for a few weeks, after that, she said that she has some other options for me to try, which aren't as dangerous as the Cyclosporene. If all else fails, we're going to re-jump start the Cyclosporene because it DID work great at first!! My allergist gets hives too, she did the Cyclosporene run as well and is now hive free!!! I'm the only patient that she's ever had that it hasn't worked for. You might want to give it a try. It's non FDA approved and you can't have grapefruit while you're on it, but it's such a low dose that it shouldn't effect you much. You do have to get blood tests from time to time to make sure your liver and kidney functions are all good though, but it'll be worth it if it works for you!!