Coadministration with telaprevir may decrease the plasma concentrations of escitalopram. The mechanism of interaction has not been described. In 13 study subjects, administration of escitalopram (10 mg once daily for 7 days) in combination with telaprevir (750 mg every 8 hours for 14 days) decreased the escitalopram peak plasma concentration (Cmax), systemic exposure (AUC) and trough plasma concentration (Cmin) by an average of 30%, 35% and 42%, respectively, compared to administration alone. Escitalopram had no significant effect on the pharmacokinetics of telaprevir.
No, his doctor didn't say specifically why he shouldn't take Lexapro while taking Incivek, she just switched him off Lexapro and onto another antidepressant before he started triple therapy. I searched it on-line for you though, and if I'm reading the information correctly, Lexapro doesn't affect how well Incivek works, but Incivek can decrease the effectiveness of Lexapro. I'm not a doctor, so I may not be interpreting it correctly, but I think that's what it's saying. I'll send you what I found on-line in a separate message.
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