Just a quick note to say hiApplesan, i finally was referred to the NIH in Bethesda Maryland. They take extremely rare problems. Did a LOT of bloodwork and testing and was desensitized to Synthroid. I saw a Dr Celi as my main physician, and he called in an allergy team. I have to be very careful about taking it at the same time every day and we are still having trouble finding a dose that i do not have a reaction to. Right now I am taking 25mcg in the morning. Not enough, but 50 is too much and my legs and joints ache sweatting and really strange dreams. I just had major surgery and cannot have bloodwork done for another 6 weeks. So I am taking the 25 right now. My pharmacist thinks that around 30 porbably will work but have to wait for the bloodwork. Hang in there--took me 3 years !!!