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These supplements can be combined with antidepressants, although caution should be exercised when combining 5-HTP with an SSRI or MAOI as it could result in serotonin syndrome. For those looking to augment a prescription antidepressant, picking a supplement that affects a different receptor complex than the antidepressant could provide additional benefits. For example, those on SSRIs like Prozac or Zoloft may wish to use L-tyrosine or DLPA to activate the dopaminergic/noradrenergic system. Similarly, those on a drug that already affects the catecholamines such as Wellbutrin, could add 5-HTP. The recent trend in antidepressant pharmacology is that hitting multiple neurotransmitter systems is better than affecting only one (29). However, many people with depression have specific symptoms that call for specialized treatment rather than a shot-gun approach.