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Thank You for answering my question on methadone and insulin usage! As a followup: I have a 41 year old brother-in-law who is diabetic and currently on a methadone treatment program. My in-laws are concerned about his mood swings from that of a very nice person to a very hateful person. He has also had episodes of not knowing where he is and does not respond to conversation. His standard comment is that it is due to the methadone and low sugar. Is it the methadone and low sugar or due to substance abuse?