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than tylenol. This is based on both personal experience,
family experience (my brother is in a lot more pain than me,
and had the worst year of his life on Celebrex), and finally,
via a Celebrex sales slime. This person is related via
marraige to me, and told us that she was aware of the
almost valueless pain management equation concerning Celebrex,
but it was her job to push it to Doctors. Scum.
I am aware of the Cox/2 issues, and I was under the impression
that Viox was the most effective of the family. Celebrex was
an accidental discovery, Viox was engineered after they
found out about it.
The key issue with the COX 1 VS 2 is that NSAIDS in general
inhibit both, and Celebrex and Viox do (mostly) just 2. COX
1 is used by the stomach lining to move mucas around,
protecting it, which means that when it gets inhibited ulcers
start because your stomach acid gets to the lining.
Concerning ecotrin (and other coated asprins), they STILL
inhibit COX 1, that just don't directly damage your lining
since they dissolve in the intestines. Since the COX 1 is
still inihibited, your own stomach acid can cause an ulcer
after extended use, you just won't realize it is connected to
the ecotrin since you didn't spit up blood when you ate it.
As far as cost, while I am not wealthly, I am well paid
as a programmer, and have a prescription plan, so it
should not enter into the picture.
Thanks for trying.
Barry
http://www.mobictablet.com/mobictabs7-5-15mg.htm
There are serious stomach bleeding issues associated
with this drug. It's an old line NSAID with COX 1
inhibition.
Oh well.
Barry
> by patients with a history of drug dependence
Wicked stuff.
Pentazocine is a real pain killer, not a real "narcotic", ie:
opoid, but will real CNS depressant and painkiller affects.
Also, highly addictive.
Naloxone is a narcotic antagonist. This means is binds
to the narcotic receptors in your nerves without stimulating
the narcotic effect, thereby blocking heroin, morphine, or
any real narcotic from working. This only happens when you
inject it, and it is in this formulation to keep addicts
from injecting it.
When my shoulder was dislocated and they gave me a real painkiller before shoving it back in, I was HAPPY. I was
so happy, I annoyed the staff, so they gave me this (I
assume), which brought me down in about 10 seconds. Bummer.
I can't accept any drugs that'll make me stupid. As a
computer programmer, I live by my wits.
Also, while Vicodan is formulated for people like me, it's
not for any real useful reason. It still get's me high,
it just has in instant tolerance, which forces you to
double and quadruple dose for the same affect. Worthless
for long term pain.
Percodan/cet, on the other hand, is FUN (or was). Not for
me any more.
And I have no idea why people consider Darvon a pain killer.
I seem to recall some studies showing the placebo as better.
Oh well
Thanks anyway
A totally benign drug that preserves complete mental clarity with zero addictive potential sounds like something from a science fiction novel.
> expecting to find.
Dunno.
That's the point of asking.
Since I've stopped watching the medical journals,
may a new non-bleeding NSAID like Viox but with
far better pain killing effects has shown up
without me noticing.
I apologize if I "sweep" away everything, but
I accept that I will be in pain if I wish to
continue my career, and I will be in the streets
destitute if I take the easy pain relief way out.
If any of the things I've said were wrong, please
let me know. I may be totally full of ****, but
until someone sets me straight, I won't know.
Maybe I was hoping for somebody to say good things
about Ultram in the context of painkilling without
addiction, since this seems to be the best available
with the lowest mind altering aspect, but it didn't
happen.
Thanks for trying.
I agree with everyone else. It seems you already read alot about this stuff, I think most of us on this board know enough about painkillers and pills to be a damn Pharmacist, or even a Doctor. Have you tried Dolobid? Naproxen? Dolobid worked for me as an NSAID but it tore my stomach up. I too am in computers, I develop websites and am always on the computer. I don't have anything wrong with my arms, hands or fingers but I do know there is a new C+ program in development, it uses voice recognition and commands. Therefore long boring scripting and useless Unix commands Via:Typing, will hopefully be null and void one day. I know it doesn't help now but, Oh well...Se'La Vi'
Take Care
Chad b
Dolobid - no, Naproxen - yes, stomach pain.
My brother (who I commute with) aready went
through the bleeding ulcer associated with
various NSAIDs, so I'm real sensitive to the
issue.
Now he's on a mix of Viox and Ultram, but he
doesn't have the same drug history as me so Ultram
is "safe".
> it uses voice recognition and commands.
Can't use them. I'm a Perl/SQL/Unix geek. They
are for dictation and canned commands. Those of use
who CREATE the commands (making up the words as you
go, variable names, etc) confuse the hell out of them.
> Therefore long boring scripting and useless Unix
> commands Via:Typing, will hopefully be null and void
> one day.
I hope not. I script someone once, and it'll run
forever. And I love doing it, so I'll put more
of an effort into keeping it that way.
Do not use Ultram as it is addictive,otherwise it would be an OTC drug,they cannot have it both ways,just aren`t that stupid are we?.
If you had the tendenitis before getting the job,you have big dilemma.If you take painkiller it does not matter whether it is addictive or not,you will seriously exacerbate your medical condition.Get a referal from your doctor for a specialist in that area(tendenitis).May need surgery soon.Your future is in your hands(arms).
Next question... what is this business about THIQ... acronym for a long name I cannot pronounce. I have heard that this "chemical" is present when pain is present and "directs" the opiate to work on the pain and not the "pleasure center"... supposedly this makes the short term use of narcotics ok for an addict..... ( sounds like a risk to me)... can you explain this to me ??? Thanks very much. Love, Brighty
I guess my question is more regarding the person who is already an addict and does not want to relapse... there is very little out there in the way of pain killers for them.... so I am wondering if the bup is a bit of a help in that I have heard it's long acting and not producing a high on a normal dose. (??)Basically my question is trying to find the lesser of the evils !!! I heard someone say that there are more people in France on buprenorphine than on methadone.... so I am wondering if it would be a bette maintenance drug than methadone since I have read that it's a much easier drug to wean off than most other narcotics. Like your mom and Maria's mom I am always looking for information because I do not want to ever see my child go through this again... and sooner or later most of us need surgery or pain relief. I am very appreciative of your input because it makes me realize that the bup is not something to consider safe by any means and we should not start thinking of it that way. Take care and I hope you have a better day today.... you are in my prayers. Love, Brighty
Am seeing my pain doctor next week and want to be off drugs soon if not NOW, and know a gradual detox is possible but am so afraid. Would Bupren be of help, any one else gone down this path and have any insights.
maryann
Love Ya!
Annie
In the end(about 2 years later) the project? was deemed a failure and shut down by the Health Dept,however,if used appropriately(sublingual) and with gradual taper and close personal councilling/obsevation,it would make an excellent step down from a strong Opioid dependence,but not in any way cure the Addiction component,for that you need specialized Psychiatric intervention and currently we have a lack of suitably trained professionals,and NO MONEY...
As far as Terahydroisoquinoline(THIQ) goes,it is present in the brains of alcoholics to a much larger degree than Normals(due to genetic reasons) and is the cause of their increased Euphoria from alcohol and subsequent alcoholism.It participates in the same Dopamine Euphoria regulation sytems that Opioids are ligands to however I am not familiar with any involvement of it in the Opioid Euphoric state.Any new knowledge or references would be appreciated.
They believe that Genetics underscores these Conditions,but have not found any Neurological or Biochemical evidence to Support this as far as I know.(I am going to look at some of the latest research papers)
N.b Practically Invariable ones first experience to Opioids produces Dysphoria not euphoria.So you may be onto something here.
The drug found me before I even knew that it existed.
I got little support from my family during those times and was mainly ostrasized in general. They cared little of the medals that adorned my uniform. I was sick and confused for a long time. Thanks to my friends in AA and my own inner strength(God)I never pulled the trigger of the gun that I had pointed at my head! J.B.
Pleasant euphoric state, including strong feeling of contentment, well-being,exquisite orgasmic tingly, luscious yum, yum like feeling all over body and brain,beautiful vivid dreams while still awake,feels like every atom in the universe is in just the right place and lack of concern with reality"sorry whats that,I forgot",shut the F..k up would you,emotions,life,death...forming part of the affective reinforcing response of the drug.
Opioid stimulation of positive reward system, normally "reserved" to species-specific `survival` behaviors, provides the kind, sensitive-human user/abuser/and rampant drug fiend deviant with an experience that brain equates(substitutes) with profoundly important events like eating, drinking, and sex-"oh how naughty,I am disgusted","I told you to keep quiet,this is important,alright","uh, oh Alrighty then Man,chill out".
Opioid-induced Sedation and Anxiolysis
Produces anxiolysis, sedation, and drowsiness,"sorry what was that again"?"ah!!!" Produces anxiolysis, sedation, and drowsiness,I said, but level of sedation is not as deep as that produced by CNS depressants."um sorry I just fell asleep could you repeat that?". I said, but level of sedation is not as deep as that produced by CNS depressants."um sorry I just fell asleep AGAIN could you repeat that?".Oh well stuff YOU, miss out then on this really important knowledge.
Mental clouding prominent, accompanied by lack of concentration, apathy, complacency, lethargy, reduced mentation, and sense of tranquility,"whats that man,you say tranquility,like in STP,wow man sounds cool,anyway what was that white powder you injected into me about 20 minutes ago,got any more"."I told you to be quiet"(silence).But in dependent people,increased mentation,motor activation,more concentration-unless you got a Liddle BId too stoned.
Anxiolytic actions from `mu` receptor inhibition of neuronal activity in locus coeruleus, (norepinephrine).
Withdrawal events will be perceived as life-threatening,"are you threatening me","Shut up PLEASE"!"you are starting to embarrass me", and subsequent physiologic reactions often lead to renewed opioid consumption.
Users self-inject for many reasons:
1. to try to re-experience `extreme` euphoria experienced after first few injections,tablets,snorts,whatever and if they stopped for a few months or more could get nicely HIGH again.
2. to maintain state of pleasure and well-being
3. to prevent mental discomfort associated with reality(reality is a disease caused by lack of drugs,we all know that!right?,anybody,help,;^ or
4. to prevent withdrawal symptoms.
Behavioral "theories" accounting for continued opioid use:especially #7.
1. Continued use avoids distress and dysphoria associated with withdrawal.
2. Euphoria produced by opioids leads to continued use.
3. Preexisting dysphoric or painful affective states are alleviated.
4. Euphoric response is an atypical response to opioids that occurs in individuals with preexistent psychopathology or Hyper sensitive Opioid/VTA systems .
5. Preexisting psychopathology/sociopathology,screwed up society or having a bad life(blame your parents,society,anybody,but yourself) may be basis for initial experimentation and euphoria, but repeated use is prompted by desire to avoid withdrawal.
6. Some individuals have deficient endorphin systems that are corrected by opioid use.
7. Repeated use of opioids leads to "permanent" dysfunction in endorphin system such that normal function requires continued use of exogenous opioids.(hmm sounds like I could exploit this one)
8. Drug effects and drug withdrawal can become linked through environmental cues and internal mood states...emotions and external cues recall distress of withdrawal or memory of opioid euphoria or opioid reduction of dysphoria or painful affective states.
And thats about it folks,I have not had any Opioids for 15 days now and I just drank a bottle of beer and feel Terrific,but nothing like that injection of heroin I had about 6 weeks ago,oh well.I did not inject any white substance before writing this,I think the beer is just SOOOOO Pleasant and gets me so High.Lucky I only got one bottle...and only drink once a week or so;getting hungry now ,goodbye and `have a nice life`.
Buprenex - this is the main thing. We both started at 4 shots a day. I am down to 1 and he is still at 3. He was addicted for much longer than I and also has Fibromyalgia.
Catapress (Clonodine) - This is actually a blood pressure med but works for some reason although I only take half at a time as I fall asleep otherwise!
Valium - for the anxiety that comes with withdrawl
Flexeril - I was also hooked on Some (which increases the effects of the oxy) so Doc gave me some lesser strenght muscle relaxers.
It is the best move I have made in my life because I feel that Oxycontin was ruining my life. I have gained 35 pounds, I never want to do anything unless I am high and I woke up each morning feeling like a truck just ran over me until I got my fix (eventually hubby just started splitting his stuff with me cuz I neeeded it).
We are not out of the woods yet, but I have not had an Oxy for over a week now and no cravings. What I am afraid of is that these detox meds give me a little buzz (more tiredness) and that I can handle being "straight" all the time. Of course, my husband is afraid of the pain coming back. But he is goint to see a new pain mgmt spec soon.
Wish us luck!
P.S. the stress test was done to check my heart because I've been having angina pains lately.
Love,
Annie
I jogged again yesterday for maybe half a mile. My knees are feeling better now. I used to laugh when my doctors suggested excersizing. Afterall, I have arthritis and a bad back! The body must need a certain amount of excersize to stay healthy. Like they say, "use it or lose it!"
About the deleted threads: I've seen this happen a few times. One time Tom and I were discussing the use of opiods to treat depression and bingo--they were gone the next day! J.B.
JB...You make me want to run outside and jump for joy....lol I can't wait till I am mended......I will go swimming, I think. Hey....this is easy on the joints, and does wonders for the heart.......Do you have access to a pool???
Good to hear from you!
Annie
Thanks and take care, Annie! J.B.
I told my doctor about the jogging and he said to take it easy and just do a brisk walk instead and practice deep breathing so I don't hyperventilate. Probably good advice for me!
Take care of yourself and be well, J.B.
I was wondering if some of you would help me with something. I read all your postings every night. I haven't disappeared.I'm still giving my daughter all the information I get from all of you. But today I need to ask you something. I wrote you about my health problems.So I won't go there again. Here's my question. I had to see my neurologist today. I have trouble walking now due to damage to my back from surgeries and disk disease. He said 3 Lortab 7.5 a day was too many. I've never increased my dosage even though I could take 4 a day. I have percocet for severe pain and I only take it when I have to. But then he told me he wants me to consider taking MS Cotin. He said it is Morphine. I don't get it. I don't get much relief from my pain med but he's worried about me taking 3 Lortab and then tells me to consider Morphine. Please, is there logic behind this? He said Morphine would be better for my pain and longer lasting. But isn't it stronger than hydros? I refuse to take anything that will make me loopy. I can't stand that feeling. He said I wouldn't get that off MS Cotin. I know some of you have a lot of knowledge on these meds. I really need some feed back on this. I also have to consider my daughter that is addicted to hydros. She thinks this is a great idea. Do you think it would be dangerous to have this drug around her? Please give me your views. I really appreciate the honesty I read on this forum. Sometimes it scares me but that's a good thing because I can be bolder with my daughter knowing the dangers. Thanks. I've told my cousin about this site. Her daughter is withdrawing from oxycotin. I hope she gets some help here as well.
Thanks again, Kerrie
Now on the issue of daughter.......Take Silicon's advice. I know in modern treatments modalities one question they sometimes ask is...Do you have a family member that is addicted. They won't prescribe in these cases. This is to avoid diversion. So maybe you shouldn't mention this. You need your meds. Let's pray that your daughter gets the help she needs. We are the one's who pay the price for diversion.
Best Wishes,
Annie