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From a legal standpoint it appears your friend left the pharmacy with the prescription, if the pharmacy was going to call the feds or local officials they would normally keep the prescription for evidence. If I read your post correctly, your friend left with the script and did not give it to the doctor either when questioned at his/her next appt. Most physicians now take photocopies of narcotic prescriptions in case there are any legal issues, however it sounds like your friend destroyed the original prescription and there pretty much goes the evidence, I am really surprised the pharmacy didn't keep the script if they suspected fraud and were informing the police.....
I would recommend your friend stop calling the doctor, wait for the next appt to talk to his/her doc, and be completely honest if she/he has a drug problem. And hopefully this incident will be enough of scare to get him/her the obvious help they need with use of narcotics.