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1. When opioids attach to the mu receptors, dopamine is released, causing pleasurable feelings to be produced.1,2
2. As opioids leave the receptors, pleasurable feelings fade and withdrawal symptoms (and possibly cravings) begin.1
3. Opioids continue leaving the mu receptors until the person is in a mild-to-moderate state of withdrawal. At this point, SUBOXONE therapy can begin.
4. The primary active ingredient in SUBOXONE—buprenorphine—attaches to the empty opioid receptors, suppressing withdrawal symptoms and reducing cravings.1 As a partial opioid agonist, SUBOXONE works by controlling withdrawal symptoms and cravings and produces a limited euphoria or "high."1
5. Buprenorphine attaches firmly to the receptors. At adequate maintenance doses, buprenorphine fills most receptors and blocks other opioids from attaching. Buprenorphine has a long duration of action, so its effects do not wear off quickly.
About SUBOXONE
SUBOXONE is the first opioid medication approved under DATA 2000 for the treatment of opioid dependence in an office-based setting. SUBOXONE also can be dispensed for take-home use, just as any other medicine for other medical conditions.
The primary active ingredient in SUBOXONE is buprenorphine.
Because buprenorphine is a partial opioid agonist, its opioid effects are limited compared with those produced by full opioid agonists, such as oxycodone or heroin. SUBOXONE also contains naloxone, an opioid antagonist.
The naloxone in SUBOXONE is there to discourage people from dissolving the tablet and injecting it. When SUBOXONE is placed under the tongue, as directed, very little naloxone reaches the bloodstream, so what the patient feels are the effects of the buprenorphine. However, if naloxone is injected, it can cause that person to quickly go into withdrawal.
SUBOXONE at the appropriate dose may be used to:
Suppress symptoms of opioid withdrawal
Decrease cravings for opioids
Reduce illicit opioid use
Block the effects of other opioids
Help patients stay in treatment
I posted in your other thread about the doctors in your area.