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1810386 tn?1405553177
Tramadol withdrawal and amitriptyline
Hi

Just wondering if anyone knew how safe it would be to take tramadol 150mg which I'm tapering down slowly hopefully to nothing in the next few weeks, is it safe to take amitriptyline (TCA) to help combat depression or do you need to be right off tramadol or a lower dose?

Any help or comments would be great thanks
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Avatar universal
Are you prescribed the TCA?  There's already an antidepressant component to Tramadol so I'd check with a doctor. Personally, I would not mix the two.

Slow tapering is perfect with Tramadol! Good luck!
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1416133 tn?1351126817
Yes I was warned about that too - something called serotonin syndrome that can come from taking an AD with tramadol.  Most Dr.'s would caution or advise against it.

And tapering is supposed to be the better way to go - I didn't taper but only because I didn't know any of that when I quit.
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I take amitriptyline too. Its great for sleeping with pain. But have to becareful with other meds. I had to stop taking it when tried citalopram and stuff like that. We aren't drs so best to call yours or ask pharmacist at cvs.
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1810386 tn?1405553177
I was prescribe  amitriptyline with topamax for migraines but I give tramadol by a different doctor in Thailand, so after I stop taking amitriptyline when I researched on the web that there was an interaction. So just wondered if anyone had experienced or knew of this interaction
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1845175 tn?1319104759
Amitriptyline and Tramadol is horible interaction leading to Serotonine Syndrome. Had it once, before surgery. any SSRI is evil with Tramal. brrrrrrr.
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1845175 tn?1319104759
Deeply sorry, people! Amitriptyline is NOT SSRI, but TCA. Don't do anything till you ask a specialst. I was on Mirtazepine and tramal, yes...
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