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GENERIC DRUG NAME: Methocarbamol
INDICATIONS AND USAGE:
Robaxin (Methocarbamol) is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute, painful musculoskeletal conditions. The mode of action of methocarbamol has not been clearly identified, but may be related to its sedative properties. Robaxin does not directly relax tense skeletal muscles in man.
CONTRAINDICATIONS:
Robaxin is contraindicated in patients hypersensitive to methocarbamol or to any of the tablet components.
WARNINGS:
Since methocarbamol may possess a general CNS depressant effect, patients receiving Robaxin should be cautioned about combined effects with alcohol and other CNS depressants.
PRECAUTIONS:
Patients should be cautioned that Robaxin may cause drowsiness or dizziness, which may impair their ability to operate motor vehicles or machinery. Because Robaxin may possess a general CNS-depressant effect, patients should be cautioned about combined effects with alcohol and other CNS depressants.
ADVERSE REACTIONS:
Adverse reactions reported coincident with the administration of methocarbamol include:
Body as a whole: Anaphylactic reaction, angioneurotic edema, fever, headache
Cardiovascular system: Bradycardia, flushing, hypotension, syncope, thrombophlebitis
Digestive system: Dyspepsia, jaundice (including cholestatic jaundice), nausea and vomiting
Hemic and lymphatic system: Leukopenia
Immune system: Hypersensitivity reactions
Nervous system: Amnesia, confusion, Diplopia, dizziness or lightheadedness, drowsiness, insomnia, mild muscular incoordination, nystagmus, sedation, seizures (including grand mal), vertigo
Skin and special senses: Blurred vision, conjunctivitis, nasal congestion, metallic taste, pruritus, rash, urticaria
DRUG INTERACTIONS:
Robaxin may inhibit the effect of pyridostigmine bromide. Therefore, Robaxin should be used with caution in patients with myasthenia gravis receiving anticholinesterase agents.
DRUG / LABORATORY TEST INTERACTIONS:
Methocarbamol may cause a color interference in certain screening tests for 5-hydroxyindoleacetic acid.
CARCINOGENESIS, MUTAGENESIS, IMPAIRMENT OF FERTILITY:
Long-term studies to evaluate the carcinogenic potential of Robaxin have not been performed. No studies have been conducted to assess the effect of Robaxin on mutagenesis or its potential to impair fertility.
PREGNANCY:
Animal reproduction studies have not been conducted with methocarbamol. It is also not known whether methocarbamol can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Robaxin should be given to a pregnant woman only if clearly needed.
Safe use of Robaxin has not been established with regard to possible adverse effects upon fetal development. There have been reports of fetal and congenital abnormalities following in utero exposure to methocarbamol. Therefore, Robaxin should not be used in women who are or may become pregnant and particularly during early pregnancy unless in the judgment of the physician the potential benefits outweigh the possible hazards.
NURSING MOTHERS:
Methocarbamol and/or its metabolites are excreted in the milk of dogs; however, it is not known whether methocarbamol or its metabolites are excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Robaxin is administered to a nursing woman.
PEDIATRIC USE:
Safety and effectiveness of Robaxin in pediatric patients below the age of 16 have not been established.
OVERDOSAGE:
Limited information is available on the acute toxicity of methocarbamol. Overdose of methocarbamol is frequently in conjunction with alcohol or other CNS depressants and includes the following symptoms:
nausea
drowsiness
blurred vision
hypotension
seizures
coma
In post-marketing experience, deaths have been reported with an overdose of methocarbamol alone or in the presence of other CNS depressants, alcohol or psychotropic drugs. Management of overdose includes symptomatic and supportive treatment.
Store Robaxin at controlled room temperature, between 20°C and 25°C (68°F and 77°F).
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Source: U.S. Food and Drug Administration, NDA 11-011/S-070/071
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Nonsteroidal Anti-Inflammatory Agent (NSAID)
Reasons not to take this medicine
If you have an allergy to aspirin, other nonsteroidal anti-inflammatory drugs(NSAIDs), diclofenac, or any other part of the medicine. A few examples of NSAIDs are ibuprofen, naproxen, diclofenac, nabumetone, and ketoprofen.
If you have porphyria.
If you are more than 24 weeks pregnant.
What is this medicine used for?
This medicine is used for the treatment of mild to moderate pain; rheumatoid arthritis, osteoarthritis, and juvenile forms of arthritis; gout; dysmenorrhea; and ankylosing spondylitis.
How does it work?
Diclofenac reduces inflammation and pain. It blocks production and release of chemicals that cause pain or inflammation.