Addiction: Substance Abuse Community
immodium addiction
About This Community:

This community is a place to share information and support with others who are trying to stop using drugs, prescription drugs, alcohol, tobacco or other addictive substances. Discuss with others, the symptoms of addiction, addiction recovery, ways to quit like tapering and cold turkey, and withdrawal symptoms. If you are interested in general "chat", please visit our Addiction Social Community.

Font Size:
A
A
A
Background:
Blank
Blank
Blank
Blank Blank

immodium addiction

Loperamide(immodium) is an opioid receptor agonist and acts on the μ-opioid receptors in the myenteric plexus large intestines; it does not affect the central nervous system like other opioids.

It works by decreasing the activity of the myenteric plexus which decreases the motility of the circular and longitudinal smooth muscles of the intestinal wall. This increases the amount of time substances stay in the intestine, allowing for more water to be absorbed out of the fecal matter. Loperamide also decreases colonic mass movements and suppresses the gastrocolic reflex.[4]

Loperamide molecules do not cross the blood-brain barrier in significant amounts, and thus it has no analgesic properties. Any that do cross the blood-brain barrier are quickly exported from the brain by P-glycoprotein (Pgp), also known as multidrug resistance protein (MDR1). Tolerance in response to long-term use has not been reported.

However, loperamide can cause physical dependence. Symptoms of opiate withdrawal have been observed in patients abruptly discontinuing long-term therapy with loperamide. For this reason, the drug was briefly classified as a Schedule V controlled substance upon its introduction.
Related Discussions
4 Comments Post a Comment
Blank
Avatar_f_tn
I head it can be used to ease withdrawal symptoms.
Blank
401095_tn?1351395370
Wow...i guess...did help me for a couple of weeks tho
Blank
452199_tn?1222186575
I read the post (wtf) so i had to do research on it and im shocked!!!
Blank
228936_tn?1249097848
WHILE IT MAY HELP WITH WITHDARWL AS FAR AS DIGESTIVE, IT DOES NOTHING FOR WITHDARWL IN MY CASE. LOMOTIL HAS A LITTLE MORE EFFECT AND IS C5 CONTROL DRUG.
Blank
Post a Comment
To
Blank
Weight Tracker
Weight Tracker
Start Tracking Now
Addiction: Substance Abuse Community Resources
RSS Expert Activity
233488_tn?1310696703
Blank
Marathon Running Done Over Many Yea...
May 21 by John C Hagan III, MD, FACS, FAAOBlank
233488_tn?1310696703
Blank
New Article on Multifocal IOL vs &q...
May 21 by John C Hagan III, MD, FACS, FAAOBlank
748543_tn?1371753642
Blank
TMJ/TMJ The Connection Between Teet...
Jan 27 by Hamidreza Nassery , DMD, FICOI, FAGDBlank
Top Addiction Answerers
Avatar_m_tn
Blank
gnarly_1
phoenix, AZ
Avatar_f_tn
Blank
jifmoc
los angeles, CA
1235186_tn?1339127464
Blank
atthebeach
on the beach, NJ
271792_tn?1334983257
Blank
IBKleen
Cumberland Plateau, TN
495284_tn?1333897642
Blank
dominosarah
City of Dominatrix, MN
Avatar_m_tn
Blank
weaver71
Other