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immodium addiction
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immodium addiction

Loperamide(immodium) is an opioid receptor agonist and acts on the μ-opioid receptors in the myenteric plexus large intestines; it does not affect the central nervous system like other opioids.

It works by decreasing the activity of the myenteric plexus which decreases the motility of the circular and longitudinal smooth muscles of the intestinal wall. This increases the amount of time substances stay in the intestine, allowing for more water to be absorbed out of the fecal matter. Loperamide also decreases colonic mass movements and suppresses the gastrocolic reflex.[4]

Loperamide molecules do not cross the blood-brain barrier in significant amounts, and thus it has no analgesic properties. Any that do cross the blood-brain barrier are quickly exported from the brain by P-glycoprotein (Pgp), also known as multidrug resistance protein (MDR1). Tolerance in response to long-term use has not been reported.

However, loperamide can cause physical dependence. Symptoms of opiate withdrawal have been observed in patients abruptly discontinuing long-term therapy with loperamide. For this reason, the drug was briefly classified as a Schedule V controlled substance upon its introduction.
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4 Comments Post a Comment
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I head it can be used to ease withdrawal symptoms.
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401095_tn?1351395370
Wow...i guess...did help me for a couple of weeks tho
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452199_tn?1222186575
I read the post (wtf) so i had to do research on it and im shocked!!!
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228936_tn?1249097848
WHILE IT MAY HELP WITH WITHDARWL AS FAR AS DIGESTIVE, IT DOES NOTHING FOR WITHDARWL IN MY CASE. LOMOTIL HAS A LITTLE MORE EFFECT AND IS C5 CONTROL DRUG.
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