to: f-rule. some facts on Sub.

Below is some facts on Sub. Bup. is the brand name.

Indications

Buprenorphine is indicated for the treatment of moderate to severe pain, peri-operative analgesia, and opioid dependence. It has a longer duration of action than morphine, and sublingual tablets offer an analgesic effect for 6 to 8 hours.[4] Australian guidelines recommend against the use of buprenorphine as an analgesic because: its effect is largely not reversed by naloxone, it may precipitate withdrawal symptoms in people dependent on other opioids, and it may cause dependence itself and has potential for misuse although it is generally viewed to be less than other opioids.[5] When used (in the high-dose formula) for opioid dependence, buprenorphine remains effective in the body for up to 72 hours in some patients, 24-48 hours typically (the mean plasma half life of buprenorphine is 37 hours, with an active metabolite as well), curbing withdrawal symptoms and antagonizing (blocking) the effects of other opioids that may be administered to the patient (legally, for pain especially in an emergency - something important for patients to address (many doctors are ignorant and/or won't prescribe proper pain relief because of the large doses and history of drug abuse), or illegally).