I have read many of the questions concerning the withdrawal of Paxil. My mother has been on Paxil - 40 mg for many years. Really no improvement in the anxiety or the depression. I then did some research on the internet and found a web site on the Mayo Clinic. They suggested having a CYP450 genotyping test. This test can determine whether a particular antidepressant will or not work for you. You have 2 enzymes that are produced in the liver. The doctor never heard of it but I insisted that he run the test. Low and behold - the test showed my mother was a "slow" metabolizer of Paxil and was literally doing nothing for her. A list of other medications that would not help were Prozac, Luvox, Paxil and a few more. The test showed that her body would do better on Zoloft or Effexor. We have started weaning her off from 40 miligrams per day to 20 miligrams per day for the first week. The second week she will start taking 12.5 mg of paxil each night and then 12.5 mg of paxil every other night for the third week. He started her on 25 miligrams of Zoloft for the first week and then it will go up to 50 miligrams. She is having some sleeping issues and confusion but I am hoping this will dissipate as one medication goes out of her body and the other one starts to kick in. To top it off, she is diabetic so you have to watch anti-depressants because they can have effects on you also. PLEASE, ask your doctor for this test.