Addison's Disease Community
ACTH interpretation
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Addison’s disease, also known as Adrenal Insufficiency or Hypocortisolism, is an endocrine disease that occurs when the adrenal glands do not produce enough of the hormone cortisol and sometimes, aldosterone. Discuss topics including symptoms and treatments for Addison’s disease.

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ACTH interpretation

Hi,
just got results back for my son RDV with his endo next wednesday, can anyone give me an idea??

cortisol  base                  156ng/ml         50-250
                                      430nmol/l        138-689

cortisol  apres 30 min         217ng/ml
                                        598/nmol  

cortisol  apres  60  min       258 ng/ml
                                        711 nmol/l

Thanks


                              
7 Comments Post a Comment
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657231_tn?1390151580
So he started in a normal, rose and rose again - he did not quite double his baseline though (that would be 312) but he consistently went  up.

So, depending on the doc, a magic number in his head - he is probably going to call this a pass.

As this is your son, I would push the endo to keep an eye on him as even though this may (or may not be) a pass - some people can pass a stim test when they are on the verge of failure and this is not a strong pass IMHO layman opinion.

Keep us posted!
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Avatar_f_tn
Hi Rumpled

For 3 days prior to the test,  he was   feeling very poorly  in general  plus  a low grade fever. On a scale of 1 to 10 for stress,  he was 12 I thought he would slap the tech... would this affect the results???    thanks I really appreciate your thoughts.
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657231_tn?1390151580
Was the doctor aware of that? Did they note that in the file?

They always say that stress can effect the results and I have even had a PICC line put in for testing to quote avoid the stress of the needle unquote - like after 20 years of being stuck (I look like an addict!) it really bothers me...


If your son was sick at the time of the test, it should have effected the test (as in raised his results - the body needs more cortisol to get over an illness) but then the stim agent would fight to raise it - so the doc - if he is smart - should factor in both. Feeling poorly will though in those that don't have good functioning adrenals cannot rise to the occasion - hence why we have to stress dose.

Normally a test would be cancelled if the person is sick so the test is done under *normal* conditions.

It will be interesting to see what the doc says. I hope the doctor thinks and does not just go by numbers only but evaluates on the whole case.
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Avatar_f_tn
Hi,

We saw the endo today,  as you predicted, she said it was normal.... Despite feeling ill and stressed, she said nothing hormonally is going on with him.....

The  cardio has said that is not the problem despite HR of around 42? Endo have said that is not the problem, despite low urea cortisol levels....no school today.   AGAIN,  sleeps around 14  16hrs a day.  

Now she will refer him to a peaditrician,  we are feeling so frustrated, as this has been going on so long,it s like banging my head agaainst a brick wall.

AAAHHHHHHHHHHHHGGGGGGHHHHHHHHHHHHH
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657231_tn?1390151580
Sorry my prediction came true - not a good thing.

I had one of my friends from the US go to France for a doc - maybe you have to come to the US? Just joking.

Search around on medical site for papers that cover adrenal diseases - see if you can find a doctor that may take your son on or know some doctor.

Doctor shopping.



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Avatar_f_tn
i am in the usa. un insured, with multiple autoimmune issues, lupus, addisons, renaulds, connective tissue disease, migraines, and the list goes on. i am not young, yet not old. i also have ptsd, anxety attacks, diverticulitis, thyroid, nodules on thyroid, which i cannot afford t get checked.  i am in pain 24 hrs a day every day. but try to make the best of it all. i had a issue in sept i was hospitalized with a bad crash. 5 days in cardiac, do not know why they put me there, no other rooms, and bp was 60/40. upon discharge, they let me go with 27 lbs of water weight gain. knowing fully well, what they were doing.  when i got into the car, i looked at my left leg, which is very hyperpigminted, and there were oozy blister like sores, breaking all over the place, went to my gp, said to go to my endo, endo sent me to a skin and vein center and after 2 mths got better, was frightening to think they may take my leg. since then i fall, a lot. i fell 3 weeks ago. insured my left leg. there is a horrible pitted oozy sore, that was getting better, however now it is red, hot and ugly. showed it to the rheumatologist yesterday. he had NO answers. idk what to do. i cannot afford another dr. i am keeping it clean etc.. but it painful as heck, and still oozy. anyone ever have  sores hard to heal? if so what did u do short of going to the er? very tired of being a guini pig here, and dont know how much more i can take. and advice would be appreciated.















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657231_tn?1390151580
If you have Addison's (as well at the multiple other auto-immune disorders that you have), it is highly probably that you are immuno-compromised and thus healing will be slow.

If you are on steroid replacements for your Addison's - which you should be - that can also inhibit healing. Depending on the dose (which given the other disorders may be higher than a normal replacement dose) you may have steroid induced Cushing's - in which case that may be creating another set of issues.

What dose of steroids are you on? Is your BP high or low? Any sodium or potassium issues? Are you replacing florinef as well?
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rumpled
Northern, NJ