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Aquagenic urticaria temporarily disappeared while taking fluconazole?
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Aquagenic urticaria temporarily disappeared while taking fluconazole?

I'm a 20-year-old female from Belgium and I've had aquagenic urticaria since I was 12. It just appeared out of the blue one day. It started on my back (the upper part), then slowly spread (day by day) to other parts as well. Now everything is "affected" after contact with water, except for my feet, legs and hands. I used to shower daily at that time - for the last two years I've been trying to shower only 3 to 4 times a week, only for a few minutes (except when I have to wash my hair).
I get these itchy(!) hives when I take a bath, when I shower, when I go swimming in a swimming pool or in the ocean, when I shower, etc. Even my own sweat triggers a reaction. Whether the water is cold or hot makes no difference. They usually appear after about 5 to 10 minutes, and it takes about one or two hours for them to disappear again.

I went to the dermatologist and she gave me an ointment with cortisone which I had to use on the hives when they would appear. The ointment made the hives disappear faster, but it did not prevent them. The dermatologist then submitted me to some allergy tests but nothing came out (except for an allergy to cobalt and nickel). So she concluded that it must be aquagenic urticaria, and told me that nothing could be done about it. She mentioned that it was possible to take other, more advanced, tests, but that these were very expensive and that they rarely produced results.
She gave me a prescription for antihistaminica (Zyrtec / Ceterizine), which prevents the hives when taken daily. This works for me, but I only use it when I go swimming in public or something like that - I don't like taking too much pills, and certainly not if I feel tired after taking them.

As for my skin in general: it's always rather dry and sensitive. Some moisturizing creams even give me allergic reactions (other than the aquagenic urticaria). But whether my skin is hydrated by a moisturizing cream or not, doesn't matter: the hives always appear.

I also seem to have some kind of allergic rhinitis, which causes symptoms related to those of having a cold. I recently went to an allergy specialist, had some ***** tests on my arms, but I wasn't allergic to any of the allergenes I was tested for. Still, the symptoms of allergic rhinitis remain...

Recently, I had to take a cure of 10 capsules of Diflucan, one capsule a week, because of recurrent vaginal yeast infections. (The active ingredient of Diflucan is "fluconazole".) This had an impact on my aquagenic urticaria. After one capsule the number of hives severely diminished, and after the second capsule, they were completely GONE. No hives, no itching, nothing. This lasted for about 10 weeks, but as soon as I stopped taking the Diflucan, the hives gradually came back. A few weeks later, the doctor prescribed me a second cure of Diflucan, and the same thing happened: after the second capsule, my symptoms of aquagenic urticaria completely disappeared. I went to see an allergy/immunology specialist, but he simply said that he didn't know where that reaction came from - and refused to think deeper about it.
If there is anyone who has similar problems, or has a similar reaction to Diflucan, please let me know!


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For those who do not want to read the entire story, this is the relevant part :)

Recently, I had to take a cure of 10 capsules of Diflucan, one capsule a week, because of recurrent vaginal yeast infections. (The active ingredient of Diflucan is "fluconazole".) This had an impact on my aquagenic urticaria. After one capsule the number of hives severely diminished, and after the second capsule, they were completely GONE. No hives, no itching, nothing. This lasted for about 10 weeks, but as soon as I stopped taking the Diflucan, the hives gradually came back. A few weeks later, the doctor prescribed me a second cure of Diflucan, and the same thing happened: after the second capsule, my symptoms of aquagenic urticaria completely disappeared. I went to see an allergy/immunology specialist, but he simply said that he didn't know where that reaction came from - and refused to think deeper about it.
If there is anyone who has similar problems, or has a similar reaction to Diflucan, please let me know!
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