Can any body guide -

[KKCAL]

I would be highly obliged in case any body on this forum guide me for - effects,reasons,diagnose and treatment for High IgE AB Penicillium quantitaive allergy?
Have done tons of research and contacting many non profit but not getting any help.

[KKCAL]

thanks,
will send you my latest CT of sinus, Eco,PFT test, after three antibiotics now doctor advised for AVELOX 400 mg for 14 days, should I start this or wait to see ENT and Cradiologist?
Last days complete blood work and urine was done, will place to you.

[mklarson]

This is a problematic fugal issue in patients with severe asthma.  The high IgE finding is for the Penicillium species, which is a prevalent indoor fungi.  Current treatment protocols include a combination asthma inhaler such as Symbicort or Dulera (might want to stay away from Advair based on your findings...fugal issues are higher with it) and an anti-fungal treatment which is chosen based on your medical history. A newer agent called Anoro by Glaxo seems to help even though it is more of a COPD adjunct medicine.  Do some homework on the new IL-5 inhibitors for asthma that should hit the market in the next year or two.  Both are finishing Phase III trails (one by Teva and one by Glaxo) and will likely be a great step forward in lessening your overall asthma/fungal problems.  You might also want to do some homework on allergic bronchopulmonary mycosis (ABPM). ABPM is  part of the total picture tied to your question.  Lastly,  check into ways of minimizing any potential household fungal issues.  The are companies that can come out and do an assessment of your house to see if it is a contributing factor.  Your local allergist or pulmonologist should be able to recommend a company for the testing.

Hope this helps...