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Developing allergies late in life

Developing allergies late in life

My wife is about 34 years old and has been having issues when taking pain medication. A month or two ago she took some Aleve it made her face swell up. Since that happened she then tried Advil and the same thing happened. She took some Excederine last night and she has a little swelling around one of her eyes and she began shaking and then for a minute or 2 was kind of was out of it. I am curious as to what could cause this. Especially so late in life. Any help would be appreciated.
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