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Cortisone is a powerful anti-inflammatory medication. A cortisone shot starts to work very quickly once injected, and most people find that relief begins within 48 to 72 hours.The duration is only 30-36 hours and is excreted in the urine or stool.
(http://www.wellness.com/adam.asp?title=Cortisone&url=http%3A//www.wellness.com/resources/Complementary%2520and%2520Alternative%2520Medicine/41/033100.htm)
Take care and regards.