SGPT values are high continually

I was on the tuberculosis medicine for last 9 months, which ended last month, I was advised for the SGPT, HB and TSH test every month. For last few months my SGPT is going out of range  and fluctuating from 50 - 140 range. Now i am not on any medication, Please advise me how dangerous these SGPT values are and what i need to do?

Thanks in advance!!

Thanks,
Dubey

[Dr Rajput]

Hi, welcome to the forum. Plasma levels of aspartate and alanine aminotransferases (AST [SGOT] and ALT [SGPT]) are routinely measured to assess liver function.

Normally SGPT level is below 40 IU/L.  SGPT is marker of liver diseases or liver conditions.

Anti tubercular drugs like isoniazid, rifampicin and pyrizinamide which are commonly given for treatment are known to cause hepatotoxicity. It is firstly evident by increase in liver enzymes. You enzyme levels suggest a mild hepatic damamge. But usually it is reversible damage i.e. once you discontinue the drug the effects over liver is reversed and it can be evident by monitoring liver enzymes regularly.

You need not worry; repeat the test after a month. If the levels lower down then it may point towards healing of damaged liver cells.

I suggest you to consult physician for next further management. Take care and regards.

[rmohapa]

Hi ,
I am 28 years old feamle and married just 7 months ago. In jan 2010 , I was deteced by Bone TB. And since march 2010 till date i am taking AKT 4 ...then AKT 3 medicines. On sunday 13th march i got my blodd test done and got SGPT and SGOT very high
SGPT - in Jan 2011 = 43 and in Mar 2011 =580
SGOT - In jan 2011 = 28 and in Mar 2011 =140
What could be the reason for sulh high levels in jus two months ?What the problem and what the treatmenmt for the same ?
Please suggest

[Dr Rajput]

Hi, welcome to the forum, anz of the three drugs i.e. isoniazid, rifampicin and pyrizinamide is responsible for this. Hence, it is important to find out the responsible agent. This can be evaluated by your health care provider. Further intake of such responsible agent should be stopped and shifted to alternative anti tubercular agents.

As I have already stated, it may be reversible damage i.e. once you discontinue the drug the effects over liver is reversed and it can be evident by monitoring liver enzymes regularly. Take care and regards.

[Dr Rajput]

Hi, welcome to the forum, any of the three drugs i.e. isoniazid, rifampicin and pyrizinamide is responsible for this. Hence, it is important to find out the responsible agent. This can be evaluated by your health care provider. Further intake of such responsible agent should be stopped and shifted to alternative anti tubercular agents.

As I have already stated, it may be reversible damage i.e. once you discontinue the drug the effects over liver is reversed and it can be evident by monitoring liver enzymes regularly. Take care and regards.

[anandbhardwaj]

Sir, My wife has been suffering from itching for the 7 months. We have met quite a few doctors of repute, have undergone ALP (~400+), SGOT (~56) and SGPT (~71) at regular intervals.  MRI and MCHP has also been performed. Liver biopsy was done some 10 days back. Almost all the test have been conducted with normal results. She is presently on ursodil sr and atarax.
Yet Her itching persists and it is adding a lot of problem. I would be very thankful to you if you could suggest some recourse or advise us to a doctor whom we can meet.
My co-ordinates are
Anand Bhardwaj Sharma
Mob:[phone]
email: anand.***@****