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allergy or autoimmune?
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allergy or autoimmune?

I have had chronic hives and major swelling of the lips, tounge, fingers, toes, even my skull, since the last week of January.  I was on steroids and antihistimes without any relief.  The allergist did blood tests and found my IgE levels were very high so he gave me a shot of Xolair to combat them to see if they would stop hives.  It did not.  He did more blood work and saw my IgG levels were high, my white blood count was high and I tested positive for ANA.  I was then sent to a dermatologist who did a biopsy and more blood work. The biopsy showed Urticaria Vasculities and blood showed my SPEP levels were off and he suggested a hemotologist...I am at loss for words and at the end of the rope.  I have lots of weird things that have been going on with me besides hives, like loss of hair, major sweating, tingeling in my fingers and arms, thowing up, stomach pains, diarhea (diarrhea), bad memory, headaches, hallucinations, trouble sleeping, extreme fatigue.. please help!
Avatar_dr_f_tn
Hello and hope you are doing well.

The cause for urticaria vasculitis is usually not known. The symptoms mentioned by you could be due to urticaria vasculitis. Treatment of urticarial vasculitis is based on systemic effects of the disease, extent of skin involvement, and previous response to treatment. For patients with skin involvement only, antihistamines or nonsteroidal anti-inflammatory drugs (NSAIDs) may provide symptomatic relief. If these agents fail, colchicine, hydroxychloroquine, or dapsone may be effective. If all other treatment modalities have failed or if the patient has systemic involvement, consider initiating treatment with glucocorticoids.

Discuss these options with your consulting doctor.

Hope this helped and do keep us posted.
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