Aa
donating plasma does effect my immune system
will donating plasma lower my immune system
This is troubling: http://www.ncbi.nlm.nih.gov/pubmed/8053039
Abstract
BACKGROUND:
The possible effects of long-term plasma donation remain unknown, but it is important to investigate them so that donor safety is ensured. The purpose of this study was to determine if long-term plasma donation alters plasma proteins or lymphocyte phenotypes.
STUDY DESIGN AND METHODS:
Two groups of long-term plasma donors, source plasma donors (n = 20) and Rh immune globulin plasma donors (n = 26), were compared with whole blood donors (n = 29) and nondonor controls (n = 30). Blood samples were obtained prior to donation. Serum protein, albumin, globulin, and immunoglobulin levels were determined. In an assay using whole blood, lymphocyte phenotypes were characterized with a panel of single- and dual-labeled monoclonal antibodies and subsequent analysis by flow cytometry.
RESULTS:
As compared to the nondonor controls and/or whole blood donors, the mean values for serum protein, globulin, and IgG levels were lower in both plasma donor groups, with a significant negative correlation between donation frequency and serum protein values for the source plasma donors. Albumin levels were within normal ranges for both groups of plasma donors. No significant differences existed among the donor groups in total white cell counts, the percentage or absolute number of lymphocytes, T (CD3) cells, or helper T (CD4) cells. However, there were increased percentages of B (CD19) cells and decreased percentages of suppressor T (CD8+/CD11b+) cells and natural killer cells in both groups of plasma donors as compared to nondonor controls.
CONCLUSION:
Many plasma donors have low levels of serum protein, globulin, and IgG. In addition, they have increased percentages of B cells and decreased percentages of suppressor T and natural killer cells. The clinical significance of these findings warrants further investigation.
Abstract
BACKGROUND:
The possible effects of long-term plasma donation remain unknown, but it is important to investigate them so that donor safety is ensured. The purpose of this study was to determine if long-term plasma donation alters plasma proteins or lymphocyte phenotypes.
STUDY DESIGN AND METHODS:
Two groups of long-term plasma donors, source plasma donors (n = 20) and Rh immune globulin plasma donors (n = 26), were compared with whole blood donors (n = 29) and nondonor controls (n = 30). Blood samples were obtained prior to donation. Serum protein, albumin, globulin, and immunoglobulin levels were determined. In an assay using whole blood, lymphocyte phenotypes were characterized with a panel of single- and dual-labeled monoclonal antibodies and subsequent analysis by flow cytometry.
RESULTS:
As compared to the nondonor controls and/or whole blood donors, the mean values for serum protein, globulin, and IgG levels were lower in both plasma donor groups, with a significant negative correlation between donation frequency and serum protein values for the source plasma donors. Albumin levels were within normal ranges for both groups of plasma donors. No significant differences existed among the donor groups in total white cell counts, the percentage or absolute number of lymphocytes, T (CD3) cells, or helper T (CD4) cells. However, there were increased percentages of B (CD19) cells and decreased percentages of suppressor T (CD8+/CD11b+) cells and natural killer cells in both groups of plasma donors as compared to nondonor controls.
CONCLUSION:
Many plasma donors have low levels of serum protein, globulin, and IgG. In addition, they have increased percentages of B cells and decreased percentages of suppressor T and natural killer cells. The clinical significance of these findings warrants further investigation.
Anyone else get a weird, random rash on their arm or arms at the site they drew plasma from? I had decided to quit donating about 6 months ago and didn't really have any side-effects from it. Except now, I have a few bumps that have risen around the area where they poked me to draw my plasma and they're red and itchy. I am quite concerned considering I have not been in so many months. If they don't go away within the next few days I will definitely be having some blood tests done. I am just curious if anyone else has had the same thing. (I did donate regularly, twice a week, for about a year).
the swelling may be due to the salt water saline solution they use to replace your plasma. I can feel the puffiness in my face from it immediately after donating.
the swelling may be due to the salt water saline solution they use to replace your plasma. I can feel the puffiness in my face from it immediately after donating.
I've recently experienced exactly what you mention:
I too have experienced swelling of my feet and ankles. I quit donating after my last session because not only did my feet and ankles swell but my whole body did and it's been about a week since I donated and the swelling has reduced down to just being my feet and ankles. It's been a slow healing process. The donation place tried to say it had to be something I'm doing or not doing. I beg to differ because I was completely healthy, eat organic, only drink water(lots) before I donated. Needless to say, I won't be donating anytime soon.
I too have experienced swelling of my feet and ankles. I quit donating after my last session because not only did my feet and ankles swell but my whole body did and it's been about a week since I donated and the swelling has reduced down to just being my feet and ankles. It's been a slow healing process. The donation place tried to say it had to be something I'm doing or not doing. I beg to differ because I was completely healthy, eat organic, only drink water(lots) before I donated. Needless to say, I won't be donating anytime soon.
I too have experienced swelling of my feet and ankles. I quit donating after my last session because not only did my feet and ankles swell but my whole body did and it's been about a week since I donated and the swelling has reduced down to just being my feet and ankles. It's been a slow healing process. The donation place tried to say it had to be something I'm doing or not doing. I beg to differ because I was completely healthy, eat organic, only drink water(lots) before I donated. Needless to say, I won't be donating anytime soon.
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