JRD

Any chance for these pups if JRD?

[Arnold L Goldman, D.V.M.]

Dear Dr. Petersen,

To my knowledge, your findings indicate a poor prognosis. A search of VIN, an online consultation service in the US reveals this, with respect to the disease in some other breeds: . See below and hope it helps.  Best regards to you.

Arnold L. Goldman DVM, MS
MedHelp and PDOC

Search Result #: 1 - Is Juvenile Renal Dysplasia Familial In The German Shepherd Dog.   Author(s): Ben Davidson; Julie Fischer
Hi everyone,

i have a client who is a German Shepherd breeder, very concerned about the recent import to NZ of a stud dog GSD who there are rumours may be "carrying" JRD.

In trying to research this disease for her, i am unable to find any reports of this disease as an inherited/familial condition in this breed....

Can anyone shed any light on this for me, or point me in the direction of a good vet resource describing the condition and its inheritance?
Thanks a lot!!

Julie Fischer on 04/17/2008 8:57:22 pm ET

Hi Ben -

There is no literature to support it that I know of, but in my (and other nephrologists') experience, this breed does seem substantially over-represented for this disease.
Julie Fischer, DVM, DACVIM
UCVMC-San Diego
Nephrology/Urology/Hemodialysis

Ben Davidson on 04/20/2008 8:51:05 pm ET

Thanks for the reply Julie,

do you know if any genetic testing is available, or is it a clinical diagnosis? Do you know if it is an autosomal recessive - type inheritance?
Thanks again!
  
Julie Fischer on 04/22/2008 0:05:03 am ET

In general, dysplasia is a clinical diagnosis based on signalment and ruling out other causes of chronic renal injury in a juvenile. There may be a test for shih tzu/lhasas, but I'm not sure, and we don't know if the genetic defect causing dysplasia is the same across breeds. The inheritance is not clearly defined, and we know that some dogs are much more severely affected than others.

Definitive dx is histopathological, though it's not usually necessary or particularly clinically helpful. Generally signalment, labs, and US imaging are sufficient to be pretty darn sure of the diagnosis.
Julie Fischer, DVM, DACVIM
UCVMC-San Diego
Nephrology/Urology/Hemodialysis
  
Search Result #: 2 - Juvenile nephropathy in 37 boxer dogs
Source: JOURNALS ABSTRACT (J Small Anim Pract. December 2007;48(12):690-4. JOURNAL ARTICLE)
Author(s): M L Chandler; C Elwood; K F Murphy; I Gajanayake; H M Syme
Address (URL): http://www.vin.com/Members/Journals/Journal.plx?AID=1508718


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Juvenile nephropathy in 37 boxer dogs
J Small Anim Pract. December 2007;48(12):690-4.
1M L Chandler; C Elwood; K F Murphy; I Gajanayake; H M Syme
1Hospital for Small Animals, University of Edinburgh, Easter Bush Veterinary Centre, Roslin, Midlothian EH25 9RG, UK.

Abstract
OBJECTIVES: The purpose of this study was to review and characterise the clinical presentation of young boxer dogs with chronic kidney disease referred to the authors' institutions. METHODS: Records were collected retrospectively from 37 boxer dogs, less than five years of age, which had presented with azotaemia, inappropriately low urine concentrating ability, and ultrasound or radiographic evidence of abnormal kidneys. RESULTS: Clinicopathological findings included azotaemia, hyperphosphataemia, anaemia, isosthenuria and proteinuria. Ultrasonographic findings included hyperechoic renal cortices, loss of corticomedullary junction definition, dilated pelves and irregularly shaped small kidneys. Renal histopathological findings included pericapsular and interstitial fibrosis, inflammatory cell infiltration, dilated tubules, sclerotic glomeruli and dystrophic calcification. Survival time of the dogs varied from zero to over five years after diagnosis. CLINICAL SIGNIFICANCE: This paper documents features of the presentation and progression of juvenile nephropathy in boxer dogs. While juvenile nephropathy has been reported in individual cases of boxer dogs previously, this is the first reported case series.


Search Result #: 3 - Renal pathology and urinary protein excretion in a 14-month-old Bernese mountain dog with chronic renal failure
Source: JOURNALS ABSTRACT (J Vet Med A Physiol Pathol Clin Med. April 2007;54(3):131-5.)
Author(s): J Raila; H Aupperle; G Raila; H-A Schoon; F J Schweigert
Address (URL): http://www.vin.com/Members/Journals/Journal.plx?AID=1484747


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Renal pathology and urinary protein excretion in a 14-month-old Bernese mountain dog with chronic renal failure
J Vet Med A Physiol Pathol Clin Med. April 2007;54(3):131-5.
1J Raila; H Aupperle; G Raila; H-A Schoon; F J Schweigert
1Institute of Nutritional Science, University of Potsdam, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal (Potsdam-Rehbrücke), Germany.

Abstract
The renal pathology and urinary protein pattern of a 14-month-old female Bernese mountain dog with chronic renal failure was investigated. Sodium dodecyl sulphate-polyacrylamid gel electrophoresis and subsequent Western blot analysis of urine showed the presence of heavy and light chains of immunoglobulin, transferrin, albumin, vitamin D-binding protein, transthyretin and retinol-binding protein (RBP), but no excretion of Tamm-Horsfall protein (THP). Histopathological examinations of the kidneys revealed severe membranous glomerulonephritis accompanied by tubular dilatation, tubular atrophy and interstitial fibrosis. The renal expression of megalin, the main endocytic receptor for the re-uptake of proteins in proximal tubules, RBP and THP was reduced or completely absent, indicating severe tubular dysfunction. The identified urinary proteins may be of interest as additional markers for the diagnosis of juvenile nephropathy in Bernese mountain dogs.