Alpha blockers and Duloxetine

[Jason7784]

Does anyone know if alpha blockers negate the positive effects of Duloxetine? It seems that if norepinephrine is blocked via the alpha blocker than it would cancel out the effect of the norepinephrine re-uptake and subsequent positive effects of an SNRI.

[Paxiled]

You don't say why you're taking the alpha blocker, and you're posting in the anxiety forum but taking Cymbalta, which is usually used for primary depression rather than primary anxiety as its effects on norepinephrine you're talking about can be very stimulating -- intentionally so to get depressed people going again but can cause anxiety because of this.  None of us on here are pharmacologists, so this is a question for your psychiatrist or perhaps a pharmacist.