Anxiety Community
Ryan7591 : Clonazepam plasma levels
About This Community:

A community of people with Anxiety offering support through your health journey. Ask a question, join a conversation, share experiences: sleeping, mood swings, panic attacks, and disorders.

Font Size:
A
A
A
Background:
Blank
Blank
Blank
Blank Blank

Ryan7591 : Clonazepam plasma levels

Ive been taking .25 mg qid of clonazepam for 9 months.  i still feel anxiety and panic feelings.  would taking .5 mg tid increase the levels in my plasma?  i realize that 1.5 mg a day is more than 1 mg, but have heard ryan say that the more times a day you take it the more it increases in your plasma.  so .25 mg a day will result in higher concentrations than 1 mg once a day.  so what would have higher concentration of plasma levels, .25 qid or .5 tid?
Related Discussions
5 Comments Post a Comment
Blank
Avatar n tn
thanks for that info.  on a side note, if i wanted to stay on a total of 1mg a day, if i stopped taking .25 qid and instead took .5 bid, would this change in plasma levels increase the risk of tolerance developing.  i know you say tolerance isnt an issue bc constatn plasma levels are maintained.  so i dont want my plasma levels to flucuate if this is a problem.  if it isnt a problem, how often can i make a change?  or do i need to stay the same for a long time.  i DONT want to do anything that will cause tolerance.  i think im going to take .5 bid because i have a hard time taking a pill qid.  also i am now taking brand name klonopin instead of teva and can tell its more powerful.  .5 mg of klonopin is noticeably stronger than .5 of teva clonazapam.  so i am hoping that the .5 bid is just as good or better than the weaker teva at .25 qid.  i greatly appreciate your knowledge and willingness to help others.
Blank
433485 tn?1321816990
Hi Ryan.  I have read many of your posts on here and am so grateful how you are so helpful.  I have a question about this post:  I take Klonopin .5 3 times a day.  I also take 60 mg. of Celexa.  I have been experiencing severe anxiety so my doc added 100 mg of Wellbutrin.  It has been a week since the Wellbutrin and I seem to be seeing a small positive change.  However, my question is about the Klonopin.  It has always worked well for me.  I have been on it for a few years.  I am wondering what is meant by the plasma levels, but most importantly, about the tolerance.  I am diagnosed clinical depressive ( since age 9) and about a year and a half ago, diagnosed GAD, after major surgery.  I am so afraid of developing a tolerance to the Klonopin,i.e. it not working any more.  Feedback?  Thanks so much.  Sue
Blank
Avatar f tn
You can reach tolerance with klonopin--it happens to a lot of people. To say you cannot reach tolerance with klonopin is untrue. Eventually, you will. The withdrawals can be horrible. Everyone's body is different. You are on low doses--stay there! Look up the word benzodiazepine and research it. Find out what's involved with tapering off when need be. It takes a while even on low dose klonopin to withdrawal but if done properly you will be fine. Don't updose! Wikipedia is very informative about benzodiazepine drugs.

Advise from a neurologist at John Hopkins Hospital for anxiety is CBT.


Best to you,

abby
Blank
Avatar f tn
I know many people that report great complications with Klonopin after withdrawaling-- yourself included. Unless there are two Ryans on this site, (If so I truly apolozize). The binding capacity of Klonopin is believed to be the very reason for this problem. This has not been proven in a lab, but sometimes experience is the best teacher, as it has been proven that the pharmas fudge their stats--and the FDA knows it.

I truly believe in the benefits of Klonopin. I do know anxiety. But benzos are very powerful drugs. As I have stated before, Klonopin should be used for short term use only with a taper plan. What a drag when a doctor just yanks someone off their medication.

BTW your post on pharmacies was really very impressive. I have yet to have a pharmacist admitt that there is any difference between generic and brand. But when I look at their face... I'm not so sure. Doesn't the pharmacy owe their fuduciary responsibility to the customer.

abby
Blank
433485 tn?1321816990
Hi.  I had added a post to this one but fear it may have been overlooked.  You seem very knowledgable about benzos.  Can you develop a tolerance to Klonopin in that .5 mg 3 times a day would stop working?  It is a drug I have been on for a few years now and works well.  That is one of my fears: that it will stop working.  Thanks so much
Sue
Blank
Avatar f tn
Are there any posts on this site that are more recent than 2 years ago; say like this year (2011)? Just curious. My nickname is steepedinmadness & I'd appreciate hearing from any recent posters who are having problems with not only clonazepam, but also alprazolam & tramadol. Thanks
Blank
Post a Comment
To
Recent Activity
4059843 tn?1454481984
Blank
mishymoshymarcy If you think you've tried y... Comment
3 hrs ago
1851352 tn?1437742010
Blank
rocketgirl1210 I have returned! :) Comment
13 hrs ago
406584 tn?1399591666
Blank
refills, and 10356 commented on clean_in_ks's status
17 hrs ago
Blank
Anxiety Tracker
Track Anxiety Symptoms
Start Tracking Now
Top Anxiety Answerers
Avatar universal
Blank
358304 tn?1409713092
Blank
na, MO
Avatar universal
Blank
Arlington, VA
675718 tn?1449992146
Blank
El Paso, TX
Avatar universal
Blank
MI
Avatar universal
Blank
Anxiety Community Resources
RSS Expert Activity
233488 tn?1310696703
Blank
Marathon Running Done Over Many Yea...
May 21 by John C Hagan III, MD, FACS, FAAOBlank
233488 tn?1310696703
Blank
New Article on Multifocal IOL vs &q...
May 21 by John C Hagan III, MD, FACS, FAAOBlank
748543 tn?1443740527
Blank
TMJ/TMJ The Connection Between Teet...
01/15 by Hamidreza Nassery , DMD, FICOI, FAGD, FICCMOBlank
Top Anxiety Answerers
Avatar universal
Blank
358304 tn?1409713092
Blank
na, MO
Avatar universal
Blank
Arlington, VA
675718 tn?1449992146
Blank
El Paso, TX
Avatar universal
Blank
MI
Avatar universal
Blank