Nutrition Health Chat: Tuesday, Dec. 8th, 5-6 PM Eastern. Learn how vitamins, minerals, and phytonutrients affect your health. Free live Q&A. Join us!
Member Comments are provided by individuals and reflect their personal opinions only. Under NO circumstances should you act on any advice or opinion posted in this forum. ALWAYS check with your personal physician before taking any action regarding your health! MedHelp International and our partners, sponsors and affiliates have no obligation to monitor any comments posted on this site, or the content and/or accuracy of such exchanges. MedHelp International does not endorse the views of any user.
Would this route of administration work similar to faster acting benzodiazepines such as Xanax or Ativan, or does it depend solely on having a steady amount of KlonopinKlonopin Klonopin wafer in your bloodstream already?
I'm confused; why would a doctor prescribe KlonopinKlonopin Klonopin wafer for anxiety attacks (i.e., take it as needed)?
Thirty minutes for KlonopinKlonopin Klonopin wafer. The disintegtating wafers are not necessary, as the tablets may be used in the exact same fashion. All of the Benzodiazepines can be taken sublingually, albeit their duration of action will be reduced, as peak plasma levels are obtained quicker via this route of administration, and, hence, they are eliminated more rapidly.
The only instance where steady-state would enter the picture with Klonopin is if you were previously taking a shorter-acting Benzodiazepine over the long-term, such as Ativan, Serax or Xanax. In that instance, the Klonopin would not instantaneouly replace those, but rather would need to accumulate. A single sublingual dose of Klonopin in that instance would have little to no effect, or the effect may be very short-lived (2-4 hours).
For p.r.n. use, Xanax would be the best in terms of onset - either PO or sublingually. Even though the onset of action for Klonopin is increased via the sublingual route, Xanax reaches peak plasma levels much more rapidly. Klonopin peaks between 2-4 hours via the PO route, and between 1-2 hours via the sublingual route.
If you have had no previous exposure to short-acting Benzodiazepines, Klonopin can be used on a p.r.n. basis either PO or sublingually. If you've had exposure to the short-acting agents, Xanax should be used at an equivalent dosage of 2 milligrams for guaranteed efficacy.
^quote
Thirty minutes for Klonopin. The disintegtating wafers are not necessary, as the tablets may be used in the exact same fashion. All of the Benzodiazepines can be taken sublingually, albeit their duration of action will be reduced, as peak plasma levels are obtained quicker via this route of administration, and, hence, they are eliminated more rapidly.
The only instance where steady-state would enter the picture with Klonopin is if you were previously taking a shorter-acting Benzodiazepine over the long-term, such as Ativan, Serax or Xanax. In that instance, the Klonopin would not instantaneouly replace those, but rather would need to accumulate. A single sublingual dose of Klonopin in that instance would have little to no effect, or the effect may be very short-lived (2-4 hours).
For p.r.n. use, Xanax would be the best in terms of onset - either PO or sublingually. Even though the onset of action for Klonopin is increased via the sublingual route, Xanax reaches peak plasma levels much more rapidly. Klonopin peaks between 2-4 hours via the PO route, and between 1-2 hours via the sublingual route.
If you have had no previous exposure to short-acting Benzodiazepines, Klonopin can be used on a p.r.n. basis either PO or sublingually. If you've had exposure to the short-acting agents, Xanax should be used at an equivalent dosage of 2 milligrams for guaranteed efficacy.
-Ryan