Anxiety Community
Zoloft and Grapefruit Interaction
About This Community:

A community of people with Anxiety offering support through your health journey. Ask a question, join a conversation, share experiences: sleeping, mood swings, panic attacks, and disorders.

Font Size:
A
A
A
Background:
Blank
Blank
Blank
Blank Blank

Zoloft and Grapefruit Interaction

Has anyone had problems with Zoloft side effects as a result of eating grapefruits?  I started taking zoloft (100 mg daily) just two months ago and have not gotten over what I thought were the initial symptoms--dizziness, drowsiness, itchy skin.  I was so tired all day long that I found I had to drink up to 7 cups of coffee a day to stay awake.  While reading an old magazine, one title jumped out at me, "Grapefruit Concern".  It went on to mention certain prescription drugs that are affected by eating grapefruit and its juice.  Typically, I eat two grapefruits a day!  When I called my pharmacist, he said that it wasn't a drug that showed a high incidence of interaction with grapefruit, unlike the cholesterol lowering drugs.  (Internet searches clearly showed that there is a connection).  The pharmacist did however, say, that I should skip that night's dose and try to taper off.  After just a few days, my energy has returned and I hope to get off this drug completely. As I was only on it for two months, how slowly do I have go to wean myself off it?  Is one week alright?
Related Discussions
2 Comments Post a Comment
Blank
Avatar_n_tn
Grapefruit has been proven to inhibit the cytochrome P450 enzyme group in the liver. These enzymes are chiefly responsible for the breakdown of Zoloft in your body. Given your grapefruit intake, it can be said that you're probably getting too much medication.

I would speak with your doctor about tapering off the Zoloft. One week is far too quick even if you've only been on the medication a few months. The dizziness you speak of as a side effect would certainly get worse following a rapid discontinuation.

Also, you may want to try tapering to a lower dose and holding there, thus decreasing side effects but giving the drug a chance to work.

-I am not a doctor. Take my advice with a grain of salt and speak with your physician or pharmacist about any changes in medication or treatment.
Blank
Avatar_m_tn
I was actually advised not to eat grapefruit while on Zoloft.  As Sharejew said, it does interact with SSRIs like Zoloft.  In fact, depending on what pharmacy I used to get refills, there would be stickers on the medication bottle stating not to consume any grapefruit products....furthermore, both my pharmacist and doctor told me to stay away from grapefruit.  I am not really sure why your pharmacist gave you the advice he/she did...keep us posted.l

Blank
Post a Comment
To
Recent Activity
1110049_tn?1409405744
Blank
Not Coping
3 hrs ago by 4Maddie44
1110049_tn?1409405744
Blank
4Maddie44 had a stroke and depression... Comment
3 hrs ago
4059843_tn?1440696793
Blank
mishymoshymarcy commented on mishymoshymarcy's status
5 hrs ago
Blank
Anxiety Tracker
Track Anxiety Symptoms
Start Tracking Now
Top Anxiety Answerers
Avatar_m_tn
Blank
cj29
GA
358304_tn?1409713092
Blank
cnote
na, MO
Avatar_m_tn
Blank
Paxiled
Arlington, VA
Avatar_m_tn
Blank
LRon
MI
Avatar_m_tn
Blank
anxiety860
Avatar_f_tn
Blank
coh123
Grand Rapids, MN
Anxiety Community Resources
RSS Expert Activity
233488_tn?1310696703
Blank
Marathon Running Done Over Many Yea...
May 21 by John C Hagan III, MD, FACS, FAAOBlank
233488_tn?1310696703
Blank
New Article on Multifocal IOL vs &q...
May 21 by John C Hagan III, MD, FACS, FAAOBlank
748543_tn?1371753642
Blank
TMJ/TMJ The Connection Between Teet...
Jan 27 by Hamidreza Nassery , DMD, FICOI, FAGDBlank
Top Anxiety Answerers
Avatar_m_tn
Blank
cj29
GA
358304_tn?1409713092
Blank
cnote
na, MO
Avatar_m_tn
Blank
Paxiled
Arlington, VA
Avatar_m_tn
Blank
LRon
MI
Avatar_m_tn
Blank
anxiety860
Avatar_f_tn
Blank
coh123
Grand Rapids, MN