Aa
A
A
Close
Avatar universal
Zoloft and Grapefruit Interaction
Has anyone had problems with Zoloft side effects as a result of eating grapefruits?  I started taking zoloft (100 mg daily) just two months ago and have not gotten over what I thought were the initial symptoms--dizziness, drowsiness, itchy skin.  I was so tired all day long that I found I had to drink up to 7 cups of coffee a day to stay awake.  While reading an old magazine, one title jumped out at me, "Grapefruit Concern".  It went on to mention certain prescription drugs that are affected by eating grapefruit and its juice.  Typically, I eat two grapefruits a day!  When I called my pharmacist, he said that it wasn't a drug that showed a high incidence of interaction with grapefruit, unlike the cholesterol lowering drugs.  (Internet searches clearly showed that there is a connection).  The pharmacist did however, say, that I should skip that night's dose and try to taper off.  After just a few days, my energy has returned and I hope to get off this drug completely. As I was only on it for two months, how slowly do I have go to wean myself off it?  Is one week alright?
Cancel
2 Answers
2 Answers
Page 1 of 1
Avatar universal
Grapefruit has been proven to inhibit the cytochrome P450 enzyme group in the liver. These enzymes are chiefly responsible for the breakdown of Zoloft in your body. Given your grapefruit intake, it can be said that you're probably getting too much medication.

I would speak with your doctor about tapering off the Zoloft. One week is far too quick even if you've only been on the medication a few months. The dizziness you speak of as a side effect would certainly get worse following a rapid discontinuation.

Also, you may want to try tapering to a lower dose and holding there, thus decreasing side effects but giving the drug a chance to work.

-I am not a doctor. Take my advice with a grain of salt and speak with your physician or pharmacist about any changes in medication or treatment.
Comment
Cancel
Avatar universal
Comment
Comment
Submit Comment
Avatar universal
I was actually advised not to eat grapefruit while on Zoloft.  As Sharejew said, it does interact with SSRIs like Zoloft.  In fact, depending on what pharmacy I used to get refills, there would be stickers on the medication bottle stating not to consume any grapefruit products....furthermore, both my pharmacist and doctor told me to stay away from grapefruit.  I am not really sure why your pharmacist gave you the advice he/she did...keep us posted.l

Comment
Cancel
Avatar universal
Comment
Comment
Submit Comment
Your Answer
Avatar universal
Answer
Know how to answer? Tap here to leave your answer...
Answer
Submit Answer
A
A
Recent Activity
Avatar universal
Blank
addict3 commented on READY
40 mins ago
5986700 tn?1380794980
Blank
spider6 commented on READY
1 hr ago
406584 tn?1399591666
Blank
10356 commented on READY
9 hrs ago
Blank
Anxiety Tracker
Track Anxiety Symptoms
Start Tracking Now
Top Anxiety Answerers
Avatar m tn
Blank
anxiety860
Avatar m tn
Blank
Paxiled
Arlington, VA
358304 tn?1409713092
Blank
cnote
na, MO
675718 tn?1449992146
Blank
drifter0213
El Paso, TX
Avatar f tn
Blank
Gemfly
Avatar m tn
Blank
michigan07
Anxiety Community Resources
RSS Expert Activity
233488 tn?1310696703
Blank
Marathon Running Done Over Many Yea...
May 21 by John C Hagan III, MD, FACS, FAAOBlank
233488 tn?1310696703
Blank
New Article on Multifocal IOL vs &q...
May 21 by John C Hagan III, MD, FACS, FAAOBlank
748543 tn?1443740527
Blank
TMJ/TMJ The Connection Between Teet...
01/15 by Hamidreza Nassery , DMD, FICOI, FAGD, FICCMOBlank
Top Anxiety Answerers
Avatar m tn
Blank
anxiety860
Avatar m tn
Blank
Paxiled
Arlington, VA
358304 tn?1409713092
Blank
cnote
na, MO
675718 tn?1449992146
Blank
drifter0213
El Paso, TX
Avatar f tn
Blank
Gemfly
Avatar m tn
Blank
michigan07