kolonopins

[nickieb85]

Does anyone know how long klonopins stay in your system? Like after you quit taking then, how long does it take to completely clear your system?

[Ryan7591]

It would depend on the dosage, and the manner in which it was dosed (ie: twice daily, three times daily).

0.5 milligrams taken once daily would take roughly one month to be eliminated, one and a half months for twice daily dosing, and two months if it was dosed three times daily.

Klonopin accumulates upon repeated dosing, and depending on how it is dosed, it accumulates between 1.5 - 3 times that of the steady-state plasma value.

Using 0.5 milligrams, b.i.d. as an example, the drug would accumulate to steady-state within two weeks. After an additional two weeks, the drug would accumulate to 1.5 times that of steady-state. From the initiation of therapy, it takes one month for Klonopin to accumulate to a figure of 1.5 times beyond that of steady-state.

When discontinung the drug, the accumulation level must drop to that of steady-state (a one month process).Once steady-state is reached, the terminal elimination half-life of the drug is 50 hours, which in lay terms means that one-half of the drug remaining in your system would be eliminated every two days...

Starting dose = 0.5 mg, b.i.d. Rate of elimination after one month...

Day 2 = 0.5 mg
Day 4 = 0.25 mg
Day 6 = 0.125 mg (therapeutic threshold)
Day 8 = 0.0625 mg
Day 12 = 0.03125 mg (threshold of plasma drug testing)
Day 14 = Eliminated for all practical purposes.

Generally, when someone presents this question, they are concerned about drug testing. If that is the case, it is not a concern with Klonopin. Modern drug screening that tests for Benzodiazepines tests for a metabolite known as Oxazepam, which is an active metabolite of Valium and most Benzodiazepines. Klonopin can not be picked up on standard drug testing. It produces no active metabolites. In short, no one is looking for it.

-Ryan