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switching from paxil to zoloft?

by rita978, Aug 18, 2008 06:08PM
Tags: zoloft, paxil
Hi I have been on paxil for nine years.. I am currently 25 and feel like the paxil isnt working for me..
I also had tried stopping paxil for four months cold turkey.. it was HORRIBLE.... so i went back on 10 mgs.. now ive been on 10 mg for 3 years.. I just switched to zoloft over night.. as a doctor reccomended.. I am worried I will have paxil withdrawls symptons.. I really hope I dont.. I am taking 50 mg of zoloft..
i have felt ok since and its been four days... hopefully it will be fine..
i would just like to know anything on doing the switch drastically and if zoloft is maybe better then paxil.. from what i hear it is..
thank you
Member Comments (12)

by suzieQ1003, Aug 19, 2008 06:56AM
To: rita978 and others
I am doing the same thing but going from 37.5 Paxil Cr to 100 mg Zoloft.  Paxil increased my weight and blood pressure. I was on it in varied doses for 5 years.  I am 2 wks into switch over, cutting back paxil weekly.  I am really tired, mind is racing more.
Hope this goes okay, and my weight and blood pressure come down. Anyone else?

by rita978, Aug 19, 2008 11:34AM
Hey it feels reassuring that you are doing the same thing..
I am only on my fifth day.. my head feels a little heavier.. but in general im ok.. does it get harder.. I hear that by the third week the zoloft will be completely in your system..and you should be better...
So you are cutting down on paxil and at the same time taking the 100 mg of zoloft?
I mean sopposedly zoloft is a better drug, its more recent and its easier to get off of in the end...
anyways keep in touch..
..

by iceman97, Sep 22, 2008 11:44AM
To: Rita
Let me warm you that you will probably go through hell if you stop the medicine so fast. It takes alot I mean alot longer for the medicine to leave your system. I speak form experienece and from doing extensive reaseach. You have to wean yourself of the drug slowly. The longer you've been on it the longer it will take to wean yourself off. I took paxil for 9 years and it took me almost two years to stop the drug completly. By the way all of the ssr'is have horrible health/mental side effects. For me they were, elevated blood pressure, diabetes, hypothryroid, depression, anxiety, and I am still dealing with some of these things even after being of Paxil  for moths now. I am not trying to scare you. I am just giving you the facts here. SO do your own research. Look up the info on people who have actually  taken the drug. Look into paxilprogress.org. This site offres great advice.

by ajbg3895, Mar 31, 2009 06:25PM
To: Everyone
I just switched from Paxil to Zoloft after being on Paxil for 5 years. I am having severe nausea, but no ther side effects. Has this happened to anyone else?

by Taybey, Apr 01, 2009 02:41PM
To: all
I have been on paxil, zoloft, and many others but have come back to the paxil. its the most calming of all it takes away my anxiety and depression the others did not they seemed to have a more energy type effect on me.  The prozac was the worst my heart raced and i thought i was going to have a heart attack but the zoloft kept me awake at night and very antsy during the day, for me im sticking with paxil. Im on 10mgs right now i was on 20.

by grace231210, Sep 29, 2009 04:18PM
To: All
How does one taper off paxil to zoloft.  Does the Dr. leave you on both drugs at the same time (low dose) and then take you off one, when the other kicks in?

by Paxiled, Sep 29, 2009 04:44PM
There are different theories on this with psychiatrists, none based on anything but anecdotal experience as far as I can tell.  My own view is that one should taper completely off a medication before trying another so one can tell what symptoms are withdrawal from the old med and which are side effects of the new.  Also, new meds don't really act exactly the same as an old one, so they really can't deal with withdrawal that well.  Some are closer than others, but Paxil seems to be a pretty unique med.  There's a book called Antidepressant Survival Guide by Joseph Glanville that discusses one theory on this.  

by cdedman10, Oct 05, 2009 03:16PM
I too am switching from 37.5 mg Paxil CR to 50 mg Zoloft. I have been on Paxil for 11 years. I wish I could find that psych that prescribed it to me back when I was 16 and scream at him. Over the years Paxil has seemed to stop working for me and the wonderful doc's soultion was always, "Well...let's up the dose" and then "Well...let's try the controlled release formula. Well this fall my panic attacks got so bad that I was calling in sick to work and found myself becoming very agoraphobic so my psych recommended i switch meds. I have heard how horrendous it is to stop Paxil and was VERY anxious about this process. I was assured that since I was replacng 1 SSRI with another (Zoloft), that I "shouldnt have any problems". Yeah right. At first my doc recommended I alternate Paxil and Zoloft (i.e. take Pazil one night, then Zoloft the next) for a week. Alternating meds didnt help my panic attacks at all so doc said "try Xanax". I researched Xanax online and saw that its horribly addictive and can cause seizures during withdrawl (ala wonderful Paxil) so I decided not to go that route. My doc then said to just completely stop Paxil and begin taking the Zoloft daily. Within 2 days I became super dizzy, lost my appetite, found myself sobbing over sappy TV commercials, and alternated between feeling starving and nauseaous. I'm now on day 5 without Paxil and am unable to go to work. My doc now wants me to up Zoloft to 100mg but I HATE THAT MENTALITY of "just up it[dose]" cause thats what got me here in the first place! I'm gonna stick it out with Zoloft 50 mg for at least 2 weeks and re-evaluate then if need be. Any suggestions?

by Paxiled, Oct 05, 2009 05:36PM
First, are you seeing a psychiatrist or a regular doc?  Neither knows much about this, but regular docs know nothing.  You should have tapered off the Paxil before switching, in my opinion, because when you switch, you can't tell what's a side effect of the new med and what's withdrawal effects from the old.  If it were me, I'd go back on the Paxil, which should resolve your new symptoms, and taper off more slowly.  When I was finished doing that, and it could take a long time depending on the person, then I would try the Zoloft.  They are not equivalent drugs; no two drugs affect a person the exact same way, and Paxil is in a class by itself.  As for Xanax, it is often used short-term to mitigate the symptoms of withdrawal, so that's not so strange.  Klonopin is often used as well.  I don't think upping the Zoloft is necessarily going to do anything about your Paxil withdrawal.  Sometimes psychiatrists will use Prozac to switch, because Prozac has a long half life whereas the others have very short half lives, and getting people off Prozac tends to be easier than getting them off the short half life ssris.  Don't know if it works or not.  Good luck.  And switch docs.

by cdedman10, Oct 05, 2009 08:02PM
After spending the whole day sobbing, I called my medical doctor who told me that this was a "common side effect" of switching SSRI's however my psychologist told me that bouts of incontollable crying is NOT a typical side effect and that I should dump Zoloft (after only 5 days) and switch to Effexor. Now I'm totally confused and dont know what to do...I dont want to go back to Paxil CR because that will prolong this process of weaning and I HATE PAXIL! I wish I never took that drug to begin with...Any ideas?

by cdedman10, Oct 05, 2009 08:03PM
Whats better-Effexor or Zoloft?

by Paxiled, Oct 07, 2009 02:46AM
If you can handle the Paxil withdrawal, then okay.  If not, the only way to stop it is to go back on it and taper more slowly.  Again, neither Zoloft or Effexor, which is an entirely different class of medication, will necessarily do anything about your Paxil withdrawal, and sobbing is definitely a sign of ssri withdrawal.  I can't tell you what to do, I can only suggest, based on my experience and my reading, the proper way to go off a med, and your doc isn't doing it that way.  And if you don't like what Paxil's doing to you, you probably won't like Effexor, either.  Because Effexor tends to be more stimulating, I wouldn't want to use it while I was in withdrawal from Paxil, which is difficult enough alone, as you're learning.  I would choose Zoloft over Paxil, but again, only after I was through weaning off Paxil the recommended way, which is a slow taper, as slow as you need, and if at any time you can't handle it, go back on the last dose at which you felt fine and taper more slowly.  But all of these are your choice.  There's a book called The Antidepressant Solution by Joseph Glanville that discusses withdrawal very thoroughly.  Good luck with whatever you decide.  But again, given your doc's seeming lack of knowledge about withdrawal symptoms, I would find another to help you through this.  
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